NCT01162187

Brief Summary

All contemporary guidelines for secondary prevention in acute coronary syndromes recommend a combination of aspirin, beta-blockers, ACE-inhibitors and statins. Yet underutilisation of these drugs is common. We do not know in detail what drives underutilisation, nor what its long term consequences are for survival after discharge from hospital. Also unknown is whether potential adverse effects of underutilisation are the same for individual secondary prevention drugs. This study will assess the impact of secondary prevention underutilisation on survival.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
400,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2003

Longer than P75 for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2003

Completed
6.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2010

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

July 1, 2010

Completed
13 days until next milestone

First Posted

Study publicly available on registry

July 14, 2010

Completed
Last Updated

July 14, 2010

Status Verified

July 1, 2010

Enrollment Period

6.9 years

First QC Date

July 1, 2010

Last Update Submit

July 13, 2010

Conditions

Acute Coronary Syndrome

Keywords

secondary preventionaspirinbeta blockerACE inhibitorstatinacute coronary syndromemyocardial infarctionunstable anginatrends

Outcome Measures

Primary Outcomes (1)

  • All cause mortality

    Mortality as tracked by the Office for National Statistics

    Due to follow up an average of 3 years.

Secondary Outcomes (1)

  • Competing risks between acute coronary syndrome phenotypes

    Due to follow up an average of 3 years.

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Individuals with data entered into the Myocardial Ischaemia National Audit Project (MINAP) database in England and Wales.

You may qualify if:

  • Individuals with Acute Coronary Syndrome who have been registered with the MINAP database.

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (4)

  • National Collaborating Centre for Primary Care (UK). Post Myocardial Infarction: Secondary Prevention in Primary and Secondary Care for Patients Following a Myocardial Infarction [Internet]. London: Royal College of General Practitioners (UK); 2007 May. Available from http://www.ncbi.nlm.nih.gov/books/NBK49343/

    PMID: 21290635BACKGROUND

  • Goodman SG, Huang W, Yan AT, Budaj A, Kennelly BM, Gore JM, Fox KA, Goldberg RJ, Anderson FA Jr; Expanded Global Registry of Acute Coronary Events (GRACE2) Investigators. The expanded Global Registry of Acute Coronary Events: baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes. Am Heart J. 2009 Aug;158(2):193-201.e1-5. doi: 10.1016/j.ahj.2009.06.003.

    PMID: 19619694BACKGROUND

  • Chew DP, Anderson FA, Avezum A, Eagle KA, FitzGerald G, Gore JM, Dedrick R, Brieger D; GRACE Investigators. Six-month survival benefits associated with clinical guideline recommendations in acute coronary syndromes. Heart. 2010 Aug;96(15):1201-6. doi: 10.1136/hrt.2009.184853. Epub 2010 Jun 7.

    PMID: 20530127BACKGROUND

  • Bramlage P, Messer C, Bitterlich N, Pohlmann C, Cuneo A, Stammwitz E, Tebbenjohanns J, Gohlke H, Senges J, Tebbe U. The effect of optimal medical therapy on 1-year mortality after acute myocardial infarction. Heart. 2010 Apr;96(8):604-9. doi: 10.1136/hrt.2009.188607. Epub 2010 Mar 29.

    PMID: 20353936BACKGROUND

Related Links

MeSH Terms

Conditions

Acute Coronary SyndromeMyocardial InfarctionAngina, Unstable

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosisAngina PectorisChest PainPainNeurologic ManifestationsSigns and Symptoms

Study Officials

  • Owen M Nicholas, PhD

    University College, London

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 1, 2010

First Posted

July 14, 2010

Study Start

July 1, 2003

Primary Completion

June 1, 2010

Study Completion

June 1, 2010

Last Updated

July 14, 2010

Record last verified: 2010-07