The Rate of C-reactive Protein (CRP) Increase as a Marker for Bacterial Infections in Children

NCT01159470 | Unknown DMC

• 1 other identifier: 472010.ctil
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

Fever is one of the most common problems in pediatrics. Differentiating between bacterial infections, that require antibiotic therapy, and viral infections that resolve on their own is an important challenge for physicians. C-reactive protein (CRP) is a protein that increases in response to inflammation and its level is generally higher in bacterial infections compared to viral infections. it can be measured by a simple blood test, however its utility as a sole marker for bacterial infection is limited. The hypothesis of the study is that measuring CRP velocity, e.g the value of CRP divided by the hours since the fever started will improve the utility of CRP for the diagnosis of bacterial infections in children.

Conditions

Bacterial Infections; Viral Infection

Keywords

CRP velocity

Study Arms (2)

bacterial infection

children with fever due to bacterial infection

viral infection

children with fever due to viral infection

Eligibility Criteria

• Age: Up to 5 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

children \< 5 years of age presenting to the Emergency Department with fever

You may qualify if:

• children less than 5 years of age,
• children with no comorbidities and fever \> 38 for at least 24 hours, and
• children with no previous antibiotic therapy.

You may not qualify if:

• HIV,
• immunosuppressive conditions,
• antibiotic therapy.

Sponsors & Collaborators

• Shaare Zedek Medical Center: lead

MeSH Terms

Conditions

Bacterial Infections; Virus Diseases

Condition Hierarchy (Ancestors)

Bacterial Infections and Mycoses; Infections

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: July 8, 2010
• First Posted: July 9, 2010
• Study Start: September 1, 2010
• Primary Completion: September 1, 2011
• Study Completion: September 1, 2011
• Last Updated: July 9, 2010

Record last verified: 2010-07