Study Stopped
The affiliated study SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis) has stopped enrollment.
Mechanisms of Stroke in Intracranial Stenosis
MoSIS
1 other identifier
observational
100
1 country
1
Brief Summary
The objective of this SAMMPRIS-affiliated study is to understand the mechanisms the mechanisms that underlie ischemic stroke recurrence in high-grade intracranial atherosclerotic disease in order to determine predictors of recurrent stroke. MoSIS will evaluate 6 specific mechanisms of stroke in the medically-treated SAMMPRIS cohort: decreased antegrade flow, progression of stenosis, decreased proximal collateral flow, decreased distal collateral flow, impaired cerebrovascular reserve, and artery-to-artery embolism.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jul 2010
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 28, 2010
CompletedFirst Posted
Study publicly available on registry
June 29, 2010
CompletedStudy Start
First participant enrolled
July 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedFebruary 7, 2012
February 1, 2012
9 months
June 28, 2010
February 6, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Ischemic stroke in the territory of the stenotic artery
2 years from enrollment
Eligibility Criteria
Medical arm of the SAMMPRIS trial which includes recently symptomatic (\<30 days) high grade (70% or more)intracranial stenosis of the carotid, middle cerebral, vertebral or basilar arteries.
You may qualify if:
- Enrolled in the medical arm of SAMMPRIS, signed consent
You may not qualify if:
- For QMRA testing: contraindications to MRI; for TCD testing, abscence of ultrasonographic windows.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Miami
Miami, Florida, 33136, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Associate Professor of Neurology. Director of Cerebrovascular Division
Study Record Dates
First Submitted
June 28, 2010
First Posted
June 29, 2010
Study Start
July 1, 2010
Primary Completion
April 1, 2011
Study Completion
December 1, 2011
Last Updated
February 7, 2012
Record last verified: 2012-02