Acupuncture for Migraine: a Functional Magnetic Resonance Imaging (fMRI) Study

NCT01152632 | Completed DMC

• 1 other identifier: 30930112/C190301
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Selecting acupoints along meridians is the predominant principle in acupuncture treatment, and it is also considered to ensure acupuncture efficacy. This experiment is to investigate whether specific brain networks gradually come in formation in accordance with this kind of acupoint selection methods.

Conditions

Migraine

Keywords

acupuncture; migraine; specific acupoints; brain network

Outcome Measures

Primary Outcomes (1)

• improvement of headache frequency

  4 weeks

Study Arms (5)

specific points of Bladder meridian and Shanjiao meridian

EXPERIMENTAL

In traditional Chinese acupuncture theory, Bladder meridian and Shanjiao meridian have been considered as the main pathological meridian location of migraine. Meanwhile, specific points on both meridians have been used widely in its treatment for a long time.

Other: manual acupuncture

non-specific points of Bladder meridian and Shanjiao meridian

EXPERIMENTAL

Non-specific points of Shaoyang meridians are also used in cure of migraine. It is conventionally thought to be less effective using non-specific points than specific ones.

Other: manual acupuncture

specific points of Stomach meridian

ACTIVE COMPARATOR

Specific points of Stomache meridian for migraine were searched in Chinese ancient data. And this group is set to compare with specific points of Shaoyang meridians for their possible different brain networks.

Other: manual acupuncture

non-acupoints

PLACEBO COMPARATOR

Three non-acupoints were chosen,two of which were located on the arm and one one the leg.

Other: manual acupuncture

waiting list

NO INTERVENTION

Interventions

manual acupuncture OTHER

thirty minutes duration every time, five times per week for one course, a total four courses

Also known as: acupuncture

non-acupoints; non-specific points of Bladder meridian and Shanjiao meridian; specific points of Bladder meridian and Shanjiao meridian; specific points of Stomach meridian

Eligibility Criteria

• Age: 17 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• clinical diagnosis of non-aura Migraine formulated by the international headache society in 2004

You may not qualify if:

• people with other types of headache
• people with organic cerebral disorders
• people with primary disorders
• people in moderate or severe anxiety or depression
• people in pregnancy

Sponsors & Collaborators

• Chengdu University of Traditional Chinese Medicine: lead

Study Sites (1)

Chengdu University of Traditional Chinese Medicine

Chengdu, Sichuan, 610075, China

Location

Related Publications (1)

• Li Z, Zhou J, Lan L, Cheng S, Sun R, Gong Q, Wintermark M, Zeng F, Liang F. Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study. J Headache Pain. 2020 Dec 7;21(1):141. doi: 10.1186/s10194-020-01203-5.

  PMID: 33287704 DERIVED

MeSH Terms

Conditions

Migraine Disorders

Interventions

Acupuncture Therapy

Condition Hierarchy (Ancestors)

Headache Disorders, Primary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Complementary Therapies; Therapeutics

Study Officials

• Fanrong Liang, Master

  Chengdu University of Traditional Chinese Medicine

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 27, 2010
• First Posted: June 29, 2010
• Study Start: January 1, 2010
• Primary Completion: June 1, 2013
• Study Completion: December 1, 2013
• Last Updated: December 2, 2014

Record last verified: 2012-08

Locations

CN (1)