NCT01152424

Brief Summary

Acute eosinophilic pneumonia (AEP) is diagnosed by cell count analysis of bronchoalveolar lavage fluid. However, the performance of bronchoscopy is not easy for patients with AEP, because they usually have hypoxia. Exhaled nitric oxide (FeNO) is usually elevated in the patients with eosinophilic inflammation such as asthma, but there is no previous studies FeNO in the patients with AEP. Investigators hypothesized that FeNO elevated significantly in patients with AEP, and FeNO can be used as non-invasive diagnostic method in patients who are clinically suspected with AEP, especially when the performance of bronchoscopy is difficult.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jul 2010

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 24, 2010

Completed
5 days until next milestone

First Posted

Study publicly available on registry

June 29, 2010

Completed
2 days until next milestone

Study Start

First participant enrolled

July 1, 2010

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2011

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2011

Completed
Last Updated

June 8, 2011

Status Verified

June 1, 2011

Enrollment Period

9 months

First QC Date

June 24, 2010

Last Update Submit

June 7, 2011

Conditions

AcuteEosinophilic Pneumonia

Keywords

Acute eosinophilic pneumoniaExhaled nitric oxide

Outcome Measures

Primary Outcomes (1)

  • The difference of FeNO in AEP and Community Acquired Pneumonia

    Six months

Study Arms (2)

Acute eosinophilic pneumonia

Community acquired pneumonia

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All patients who visited the study hospital with bilateral pneumonic infiltration.

You may qualify if:

  • All patients who visited the study hospital with bilateral pneumonic infiltration.

You may not qualify if:

  • Patients who do not agree with our study protocol

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Armed Forces Capital Hospital

Seongnam, Gyeongi, 482 060, South Korea

Location

Related Publications (1)

  • Lee JE, Rhee CK, Lim JH, Lee SM, Shim YS, Lee CT, Won Lee S. Fraction of exhaled nitric oxide in patients with acute eosinophilic pneumonia. Chest. 2012 May;141(5):1267-1272. doi: 10.1378/chest.11-1303. Epub 2011 Oct 20.

    PMID: 22016484DERIVED

MeSH Terms

Conditions

Pulmonary Eosinophilia

Condition Hierarchy (Ancestors)

Lung DiseasesRespiratory Tract DiseasesHypereosinophilic SyndromeEosinophiliaLeukocyte DisordersHematologic DiseasesHemic and Lymphatic Diseases

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

June 24, 2010

First Posted

June 29, 2010

Study Start

July 1, 2010

Primary Completion

April 1, 2011

Study Completion

December 1, 2011

Last Updated

June 8, 2011

Record last verified: 2011-06

Locations

KR(1)