Role of Cord Blood Hormones and Epinephrine in the Development of Transient Tachypnea of the Newborn

NCT01149928 | Completed

• 1 other identifier: 08H3330006
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

In this prospective, cross-sectional study, the aim was to investigate the possible role of cord stress hormones; adrenocorticotropic hormone (ACTH), cortisol, epinephrine, sT3, sT4, and thyroid-stimulating hormone (TSH) in the development of Transient Tachypnea of the Newborn (TTN), via their modulatory effect on epithelial sodium channels and Na-K-ATPase.

Conditions

Wet Lung

Keywords

Fetal lung fluid; Pulmonary adaptation; Transient tachypnea of the newborn; Epinephrine; Stress hormones

Outcome Measures

Primary Outcomes (1)

• Stress response at birth, as demonstrated by cord cortisol, adrenocorticotropic hormone, epinephrine, fT3, fT4, and thyroid-stimulating hormone in late preterm and term neonates developing transient tachypnea of the newborn.

  At birth cord blood samples and perinatal data were collected from ceseraen deliveries of late preterm and term infants. Cord stress hormones of the infants with the diagnosis of TTN and gestational age matched controls were analyzed.

  postnatal first 24 hours

Study Arms (2)

C/S delivered, wet lung

C/S delivered, healthy infants

Eligibility Criteria

• Age: 34 Weeks - 40 Weeks
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Cesarean delivered, late preterm and term infants during the study period in Maternity Center of Ankara University

You may qualify if:

• Gestation age \> 34 weeks
• C/S delivered infants
• Parental consent form signed

You may not qualify if:

• Gestation age \< 34 weeks
• Maternal conditions that compromised fetal well-being (hypertensive disorder, diabetes, chorioamnionitis)
• Intrauterine growth retardation
• Congenital malformations
• Absence of parental consent

Sponsors & Collaborators

• Ankara University: lead

Related Publications (1)

• Atasay B, Ergun H, Okulu E, Mungan Akin I, Arsan S. The association between cord hormones and transient tachypnea of newborn in late preterm and term neonates who were delivered by cesarean section. J Matern Fetal Neonatal Med. 2013 Jun;26(9):877-80. doi: 10.3109/14767058.2013.765846. Epub 2013 Feb 8.

  PMID: 23311764 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Cord blood serum samples were stored.

MeSH Terms

Conditions

Pulmonary Edema; Transient Tachypnea of the Newborn

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiratory Distress Syndrome, Newborn; Respiratory Distress Syndrome; Respiration Disorders; Tachypnea; Infant, Premature, Diseases; Infant, Newborn, Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 21, 2010
• First Posted: June 24, 2010
• Study Start: September 1, 2008
• Primary Completion: August 1, 2009
• Study Completion: October 1, 2009
• Last Updated: June 24, 2010

Record last verified: 2009-10