Dietary Interventions for Muscle Mass
1 other identifier
interventional
12
1 country
1
Brief Summary
Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether meat structure plays an important role in protein digestion, to maximise the amino acid availability and to stimulate the muscle protein growth in elderly people.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2011
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 15, 2010
CompletedFirst Posted
Study publicly available on registry
June 16, 2010
CompletedStudy Start
First participant enrolled
May 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2011
CompletedSeptember 14, 2011
September 1, 2011
1 month
June 15, 2010
September 13, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Muscle protein synthesis
Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound D5phe tracer, by the enrichment of the precursor (=plasma availability).
6 h postprandial period
Secondary Outcomes (1)
Dietary amino acid plasma availability
6h postprandial period
Study Arms (2)
Beef steak
EXPERIMENTALMinced beef
EXPERIMENTALInterventions
135 gram piece of intact or minced beef meat, beef steak or minced beef resp.
Eligibility Criteria
You may qualify if:
- Non-obese male subjects (BMI\<30) between the age of 65-85 years.
You may not qualify if:
- Type II diabetes or other known diseases, use of medication, female, other ages or BMI than indicated above, participation in any regular exercise program.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Universiteit Maastricht, Bewegingswetenschappen
Maastricht, Limburg, 6229ER, Netherlands
Related Publications (3)
Mioche L, Bourdiol P, Monier S, Martin JF, Cormier D. Changes in jaw muscles activity with age: effects on food bolus properties. Physiol Behav. 2004 Sep 30;82(4):621-7. doi: 10.1016/j.physbeh.2004.05.012.
PMID: 15327909RESULTMioche L, Bourdiol P, Monier S. Chewing behaviour and bolus formation during mastication of meat with different textures. Arch Oral Biol. 2003 Mar;48(3):193-200. doi: 10.1016/s0003-9969(03)00002-5.
PMID: 12648556RESULTPennings B, Groen BB, van Dijk JW, de Lange A, Kiskini A, Kuklinski M, Senden JM, van Loon LJ. Minced beef is more rapidly digested and absorbed than beef steak, resulting in greater postprandial protein retention in older men. Am J Clin Nutr. 2013 Jul;98(1):121-8. doi: 10.3945/ajcn.112.051201. Epub 2013 May 1.
PMID: 23636241DERIVED
Related Links
Study Officials
- PRINCIPAL INVESTIGATOR
B Pennings, Ir
Maastricht University Medical Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 15, 2010
First Posted
June 16, 2010
Study Start
May 1, 2011
Primary Completion
June 1, 2011
Study Completion
June 1, 2011
Last Updated
September 14, 2011
Record last verified: 2011-09