Effects of Six Months of Moderate Resistance- Versus Endurance-Training on Muscle ATP Synthesis in First-Degree Relatives of Patients With Type 2 Diabetes

NCT01145092 | Completed

• 1 other identifier: P15656
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

Life style intervention including diet and exercise is the recommended strategy for prevention of type 2 diabetes mellitus (T2DM). First-degree relatives of patients with type 2 diabetes mellitus have an increased risk of insulin resistance and a lifetime risk of developing type 2 diabetes of 40%- 80%. Poor physical fitness is a strong indicator of an increased risk of developing diabetes. Long-term endurance exercise training has been shown to increase insulin sensitivity in sedentary young and elderly individuals, first degree relatives of patients with Type 2 diabetes, glucose intolerant obese, or Type 2 diabetic humans. In type 2 diabetic patients, non-diabetic individuals with IGT and sedentary adults after exercise training of different intensity, different duration and different frequency an increase of insulin sensitivity was found. However, despite the vast knowledge concerning beneficial effects physical activity for the prevention of T2DM (and many other chronic metabolic disorders) to date wide ranging strategies have not been realized satisfactory. Regardless of age, ethnicity, sex or health status the lack of time is the primary reason for the failure to exercise on a regular basis (or is stated as primary reason). Therefore the investigators aimed at investigating whether a controlled endurance/resistance training twice a week over 6 month might be beneficial for healthy, non obese, first degree relatives with T2DM. Therefore the investigators measure parameters associated with the prevention of T2DM like insulin sensitivity, flux through fATPase and fCK, intramyocellular and hepatocellular lipids.

Conditions

Type 2 Diabetes Mellitus; Insulin Resistance

Keywords

type 2 diabetes; exercise training; ATP-synthesis; intramyocellular lipids; hepatocellular lipids; first degree relatives of T2DM patients

Outcome Measures

Primary Outcomes (1)

• Insulin Sensitivity

  measured by oral glucose tolerance test

Secondary Outcomes (4)

• incremental test power, oxygen uptake (VO2 in ml.kg-1.min-1), "aerobic threshold" (RCP= respiratory compensation point)

• ATP-Synthesis

• liver lipid content

• skeletal muscle lipid content

Interventions

exercise training, endurance training BEHAVIORAL

The endurance training group exercised on a cycle ergometer (90% of power output determined at the respiratory compensation point = RCP). The duration of each training unit was increased with time. The resistance group trained on 8 weight machines where the workload gradually increased every 2-3 weeks. At week 13 an additional physical examination, OGTT and spiro-ergometry for adjusting the training were performed.

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• First degree relatives of type 2 diabetic patients
• Age: 18-50 years
• BMI \<30 kg/m2 (due to limited MR diameter)
• Normal routine lab tests (blood cell count, kidney, liver, pancreas, thyroid and neuromuscular function)
• Availability within the local area throughout the study
• Ability to understand and sign the consent forms

You may not qualify if:

• Current smoking
• Present drug treatment
• Regular exercise training
• Contraindications for MRS studies: claustrophobia and metalliferous implants
• Pregnancy
• HIV or Hepatitis
• Acute disease 2 weeks previous to the examination
• Heart disease
• Hypertension (RR\>140/95)
• Liver disease
• Kidney disease
• Pulmonary disease
• Thyroid disease

Sponsors & Collaborators

• Landsteiner Institut: lead
• Mein Hanusch-Krankenhaus: collaborator
• Karl-Landsteiner Institute for Endocrinology and Metabolism: collaborator
• Medical University of Vienna: collaborator
• Lund University: collaborator
• Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy: collaborator

Study Sites (1)

Landsteiner Institute

Vienna, Vienna, 1140, Austria

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Insulin Resistance

Interventions

Exercise; Endurance Training

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Hyperinsulinism

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human

Study Officials

• Michael Roden, Prof.

  Institute for Clinical Diabetology, German Diabetes Center (Leibniz Center for Diabetes Research), Department of Metabolic Diseases, Heinrich-Heine University and University Clinics Düsseldorf, Germany

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 14, 2010
• First Posted: June 16, 2010
• Study Start: February 1, 2006
• Primary Completion: March 1, 2009
• Study Completion: March 1, 2009
• Last Updated: June 16, 2010

Record last verified: 2010-06

Locations

AU (1)