Clinical Value of Left Atrial Appendage Flow for Prediction of Successful Catheter Ablation for Persistent Atrial Fibrillation

NCT01144858 | Terminated

• 1 other identifier: past-1001-ryth
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study was to determine whether left atrial appendage flow velocity, as determined using trans esophageal echocardiography (TEE), predicts the outcome after catheter ablation of persistent Atrial fibrillation( pAF).

Conditions

Persistent Atrial Fibrillation; Catheter Ablation

Keywords

atrial fibrillation; ablation catheter; left atrial appendage peak emptying velocity; tool for predicting successful catheter ablation

Outcome Measures

Primary Outcomes (1)

• termination of persistent AF by catheter ablation

Secondary Outcomes (1)

• Recurrences of AF were therefore determined from holter monitoring at 3 and 6 months or 12 leads ECG in care of symptomatic palpitation with clinical interview.

Study Arms (1)

patients with persistent atrial fibrillation ablation

Other: a complete transesophageal echocardiography

Interventions

a complete transesophageal echocardiography OTHER

All patients were evaluated by a complete transesophageal echocardiography with multiplane probes with a 7-MHz transducer before catheter ablation .LA appendage flow was obtained by placing the pulsed Doppler sample volume at the orifice of the LA appendage, after which peak flow velocities were measured and averaged within each RR interval of 10 consecutive cardiac cycles

patients with persistent atrial fibrillation ablation

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

40 consecutive patients who underwent first-time radiofrequency catheter ablation for pAF. pAF was defined as continuous AF lasting longer than 1 month, resistant to either electrical or pharmacological cardioversion

You may qualify if:

• First-time radiofrequency catheter ablation for pAF. pAF was defined as continuous AF lasting longer than 1 month, resistant to either electrical or pharmacological cardioversion.
• Informed consent

You may not qualify if:

• Severe valvular disease requiring surgery
• Valvular prosthesis
• Known severe coronary artery disease
• Atrial and/or ventricular thrombosis
• New York Heart Association functional class III to IV
• Cerebrovascular disease
• Pulmonary embolism
• Latent or manifest hyperthyroidism

Sponsors & Collaborators

• Clinique Pasteur: lead

Study Sites (1)

Clinique Pasteur

Toulouse, 43-45 Avenue de Lombez, 31076, France

Location

Related Publications (1)

• Combes S, Jacob S, Combes N, Karam N, Chaumeil A, Guy-Moyat B, Treguer F, Deplagne A, Boveda S, Marijon E, Albenque JP. Predicting favourable outcomes in the setting of radiofrequency catheter ablation of long-standing persistent atrial fibrillation: a pilot study assessing the value of left atrial appendage peak flow velocity. Arch Cardiovasc Dis. 2013 Jan;106(1):36-43. doi: 10.1016/j.acvd.2012.09.002. Epub 2012 Dec 20.

  PMID: 23374970 DERIVED

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 15, 2010
• First Posted: June 16, 2010
• Study Start: January 1, 2009
• Study Completion: December 1, 2009
• Last Updated: June 16, 2010

Record last verified: 2008-10

Locations

FR (1)