Chronic Pain Following Thoracic Surgery

NCT01144845 | Completed

• 1 other identifier: PTPS-18
• Study Type: observational
• Target: 702
• Locations: 1 country
• Sites: 1

Brief Summary

Pain that persists after the healing of a surgical wound has previously been described as an important, but often unrecognized clinical problem. Persistent postsurgical (chronic postoperative pain) is the consequence of either ongoing inflammation or more common neuropathic pain as a result of surgical damage to peripheral nerves. Previous studies have shown that chronic pain is a frequent and serious complication following thoracic surgery. However, the prevalence of chronic pain following both thoracoscopy and anterior thoracotomy in patients with pulmonary malignancies is poorly characterized and the impact of this pain on patients' lives remains unclear. Thus, this study aims to investigate the prevalence of chronic pain following thoracoscopy or anterior thoracotomy, and the severity and impact of persistent post-surgical pain on daily life. This study is working with several hypotheses: 1.) persistent postsurgical pain following lung cancer surgery is predominantly of neuropathic nature and the presence of neuropathic symptoms increases the severity of postsurgical pain and reduces the patient's quality of life, 2.) the prevalence of chronic pain is reduced over time, and 3.) less invasive thoracic surgical interventions reduces the risk of the development of chronic pain.

Conditions

Pain, Postoperative

Keywords

Thoracotomy; Thoracic Surgery; Thoracic Surgical Procedures; Thoracic Surgery, Video-Assisted; Lung Neoplasms; Thoracic Nerves

Outcome Measures

Primary Outcomes (1)

• Presence of persistent postsurgical pain

  Within 10 years after thoracic surgery

Secondary Outcomes (8)

• Location of persistent postsurgical pain

  Within 10 years after thoracic surgery

• Duration of postsurgical pain

  Within 10 years after thoracic surgery

• Course of persistent postsurgical pain

  Within 10 years after thoracic surgery

• Severity of postsurgical pain

  Within 10 years after thoracic surgery

• Characteristics of persistent postsurgical pain

  Within 10 years after thoracic surgery

Study Arms (1)

Thoracic surgical patients

Patients with pulmonary malignancies

Procedure: Thoracic surgery

Interventions

Thoracic surgery PROCEDURE

Thoracoscopy or anterior thoracotomy

Thoracic surgical patients

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who underwent thoracic surgery due to pulmonary malignancies at the Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Skejby, Denmark

You may qualify if:

• Patients who previously underwent thoracic surgery with lung resection from January 2000 to december 2009

You may not qualify if:

• Death

Sponsors & Collaborators

• University of Aarhus: lead

Study Sites (1)

Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby

Aarhus N, DK-8200, Denmark

Location

MeSH Terms

Conditions

Pain, Postoperative; Lung Neoplasms

Interventions

Thoracic Surgical Procedures

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Surgical Procedures, Operative

Study Officials

• Kasper Grosen, PhDS, MHScS, RN

  Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby, Denmark

  PRINCIPAL INVESTIGATOR

• Hans K Pilegaard, MD

  Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby, Denmark

  STUDY DIRECTOR

• Vibeke Hjortdal, MD, Professor, DMSc, PhD

  Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby, Denmark

  STUDY CHAIR

• Mogens P Jensen, MD, PhD

  Department of Rheumatology, Aarhus University Hospital, Aarhus Hospital, Denmark

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD fellow, Master of Health Sciences, RN

Study Record Dates

• First Submitted: June 14, 2010
• First Posted: June 16, 2010
• Study Start: April 1, 2010
• Primary Completion: June 1, 2010
• Study Completion: October 1, 2010
• Last Updated: August 30, 2011

Record last verified: 2011-08

Locations

DK (1)