NADPH Oxidase Polymorphisms in Obstructive Sleep Apnea Syndrome (OSAS)

NCT01141829 | Unknown

• 1 other identifier: NADPHPM2010
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Obstructive Sleep Apnea (OSA) is associated with increased oxidative stress. The major sources of Reactive Oxygen Species (ROS) in the vasculature are the NADPH oxidases. Several polymorphisms related to NADPH oxidase expression or NADPH oxidase activity has been identified. The investigators are going to compare the distribution of the allelic frequencies of A-930G and C242T polymorphisms and their possible relationship with the levels of 8-isoprostanes as a marker of oxidative stress in patients with OSA and in a control group without OSA.

Conditions

Sleep Apnea Syndrome; Oxidative Stress; Single Nucleotide Polymorphism

Keywords

NADPH oxidase

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with OSAS defined by an apnea hypopnea index (AHI)\>10 h-1 will be included in the study along with control subjects without OSAS. Participants were consequently studied at the sleep unit of Hospital Universitario Son Dureta, (Palma de Mallorca, Spain).

You may not qualify if:

• chronic obstructive pulmonary disease, liver cirrhosis, thyroid dysfunction, rheumatoid arthritis, chronic renal failure and/or psychiatric disorders.

Sponsors & Collaborators

• Sociedad Española de Neumología y Cirugía Torácica: lead
• Spanish Research Center for Respiratory Diseases: collaborator

Study Sites (1)

Hospital Universitario Son Dureta

Palma de Mallorca, Balearic Islands, 07014, Spain

RECRUITING

MeSH Terms

Conditions

Sleep Apnea Syndromes

Condition Hierarchy (Ancestors)

Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Central Study Contacts

Mónica de La Peña, MD

CONTACT

0034971175112; monica.delapena@ssib.es

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 10, 2010
• First Posted: June 11, 2010
• Last Updated: June 11, 2010

Record last verified: 2010-01

Locations

ES (1)