GWA Study in Patients With Inflammatory Bowel Disease

NCT01140789 | Recruiting DMC

• 1 other identifier: IBD GWA
• Study Type: observational
• Target: 3,600
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to identify new genes in Chinese patients that help investigators to understand the biological pathway and functions in a population in whom the incidence of Inflammatory Bowel Disease (IBD) is increasing. And to explore the genetic variations in Chinese patients with IBD.

Conditions

Crohn's Disease; Ulcerative Colitis

Outcome Measures

Primary Outcomes (1)

• To identify genetic variation among three study groups

  Data will be collected from follow up questionnaires

  2 years

Study Arms (3)

Crohn's disease patients

Diagnosis of Crohn's disease by endoscopy, radiology and histology

Ulcerative colitis patients

Diagnosis of ulcerative colitis defined by endoscopy, radiology and histology

Non-IBD patients

Ethically, sex and aged-matched controls attending clinics or endoscopy for functional upper gastrointestinal diseases or screening colonoscopy.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Crohn's disease or ulcerative colitis patients as the case groups, Patients attend clinics or endoscopy for functional upper gastrointestinal diseases or screening colonoscopy as the control group.

You may qualify if:

• Age 18 or above
• Informed consent given by patient or family
• Case group (IBD patients) Diagnosis of Crohn's disease or ulcerative colitis defined by endoscopy, radiology and histology
• Control group (non-IBD cases) Ethically, sex and aged-matched controls attending clinics or endoscopy for functional upper gastrointestinal diseases or screening colonoscopy.

You may not qualify if:

• No consent
• Controls will be excluded if they have previously been diagnosed with IBD or if they have a first or second degree relative with IBD.

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Prince of Wales Hospital

Hong Kong, Hong Kong

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood 1. Up to 50ml of blood sample will be collected and stored at -80°C. 2. Some blood samples will be sent overseas for DNA extraction and genetic analysis. Stool 3. Stool samples will be collected and stored at -80°C. Some will be analysed with PCR for norovirus and faecal calprotectin in Hong Kong. Some will be sent to Germany for transethnic response mapping.Others will be stored for future analysis. Biopsy 4. For some patients, biopsies from sigmoid will be collected, snap frozen and stored at -80°C, 1 routine biopsy may also be collected for histology. Some will be sent overseas for analysis.

MeSH Terms

Conditions

Crohn Disease; Colitis, Ulcerative

Condition Hierarchy (Ancestors)

Inflammatory Bowel Diseases; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Intestinal Diseases; Colitis; Colonic Diseases

Study Officials

• Siew C NG, PhD

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Siew C NG, PhD

CONTACT

+852 3505 3509; siewchienng@cuhk.edu.hk

Kim W AU, MSc

CONTACT

+852 3505 2640; kimau@surgery.cuhk.edu.hk

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 8, 2010
• First Posted: June 10, 2010
• Study Start: April 1, 2010
• Primary Completion (Estimated): April 1, 2037
• Study Completion (Estimated): April 1, 2037
• Last Updated: February 8, 2023

Record last verified: 2023-02

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)