Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)

NCT01139086 | Unknown

• 1 other identifier: 201003050R
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart failure (CHF). Recent studies suggested that peripheral impairment was the major cause of clinical symptoms, and mechanism may be related to neuroendocrine impairment and vascular smooth muscle dysfunction. It results in increased peripheral resistance that may influence limb blood flow, muscle fitness and activities of daily.The purposes of this study are

1. 1.to compare muscular strength, endurance, and perfusion of quadriceps between CHF patients and healthy controls by isokinetic test and near-infrared spectroscopy (NIRS) and difference in activities of daily living
2. 2.to compare endothelium function between CHF patients and healthy control subjects
3. 3.the relationship between endothelium function, muscular strength, endurance, perfusion, and metabolism of quadriceps.

Conditions

Chronic Heart Failure; Coronary Disease; Dilated Cardiomyopathy

Keywords

chronic heart failure; isokinetic test; near-infrared spectroscopy; laser Doppler flowmetry; endothelial function

Outcome Measures

Primary Outcomes (1)

• muscle strength and endurance

  Measured by biodex

  baseline

Secondary Outcomes (6)

• skeletal muscle oxygenation response

  baseline

• Walking distance in 6-minute walking test

  baseline

• laser Doppler flowmetry combine iontophoresis

  baseline

• sit-to-stand test

  baseline

• questionnaire (functional activity and quality of life)

  baseline

Study Arms (3)

Cardiovascular disease

Diagnosis of cardiomyopathy or ischemic heart disease without heart failure

Chronic heart failure

Diagnosis of cardiomyopathy or ischemic heart disease LVEF \<40%

Control

Age and body built matched with chronic heart failure group

Eligibility Criteria

• Age: 40 Years - 75 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Chronic Heart Failure Coronary Disease Dilated Cardiomyopathy Control group without diagnosis of any heart disease

You may qualify if:

• Age 40-75 years
• Chronic heart failure: ejection fraction\<40% and at stable condition
• Coronary Disease and dilated cardiomyopathy without heart failure
• Control group without diagnosis of any heart disease

You may not qualify if:

• Clinical diagnosis of neuromusculoskeletal , pulmonary, or other systemic diseases that may affect the testing of the study

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

RECRUITING

MeSH Terms

Conditions

Coronary Disease; Cardiomyopathy, Dilated

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Cardiomegaly; Cardiomyopathies; Laminopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Ying-Tai Wu, Ph.D

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ying-Tai Wu, Ph.D

CONTACT

+886-2-33668129; ytw@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 7, 2010
• First Posted: June 8, 2010
• Study Start: May 1, 2010
• Primary Completion: May 1, 2011
• Study Completion: May 1, 2011
• Last Updated: June 8, 2010

Record last verified: 2010-06

Locations

TW (1)