NCT01137435

Brief Summary

This safety surveillance study is being conducted in accordance with Korea Food and Drug Administration (KFDA) Notification No. 2009-46 "Basic standard for reexamination of new drug". The study objective is to assess within 30 days post-administration, the safety of ADACEL™ administered under the real clinical practice.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
659

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started Jun 2010

Longer than P75 for phase_4

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2010

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

June 3, 2010

Completed
1 day until next milestone

First Posted

Study publicly available on registry

June 4, 2010

Completed
5.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2016

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2016

Completed
4 months until next milestone

Results Posted

Study results publicly available

January 4, 2017

Completed
Last Updated

April 28, 2022

Status Verified

March 1, 2022

Enrollment Period

5.8 years

First QC Date

June 3, 2010

Results QC Date

November 6, 2016

Last Update Submit

March 30, 2022

Conditions

Keywords

AdacelDiphtheriaTetanusPertussis

Outcome Measures

Primary Outcomes (1)

  • Summary of Adverse Events Reported in Participants That Received a Single Intramuscular Dose of Adacel™

    All adverse event reported by vaccinated subjects within 30 days post-vaccination during the 6 year post marketing surveillance period.

    30 days post-vaccination

Other Outcomes (3)

  • Number of Participants Reporting Unexpected Adverse Events After A Single Intramuscular Dose of Adacel™

    30 days post-vaccination

  • Number of Participants Reporting Adverse Events After A Single Intramuscular Dose of Adacel™

    30 days post-vaccination

  • Number of Reported Solicited Injection-Site and Systemic Events Following A Single Intramuscular Dose of Adacel™

    7 days post-vaccination

Study Arms (1)

Study Group

EXPERIMENTAL
Biological: ADACEL™:Adsorbed Diphtheria, Tetanus Toxoids and Component Pertussis Combined

Interventions

0.5 mL, intramuscular (IM)

Also known as: Adacel™
Study Group

Eligibility Criteria

Age11 Years - 64 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Subjects who are 11 through 64 years of age (as indicated in the currently approved local product labeling) , who are given a single dose of the study vaccine, during a routine health-care visit, as active booster immunization for the prevention of tetanus, diphtheria and pertussis.
  • Written informed consent obtained from the subject. For subjects below the legal age of consent, written informed consent must be obtained from the parent or legal guardian (legally acceptable representative -LAR) of the subject.

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Unknown Facility

Jung-gu, Incheon, South Korea

Location

Unknown Facility

Seoul, South Korea

Location

Related Links

MeSH Terms

Conditions

DiphtheriaTetanusWhooping Cough

Interventions

Tetanus Toxoidadacel

Condition Hierarchy (Ancestors)

Corynebacterium InfectionsActinomycetales InfectionsGram-Positive Bacterial InfectionsBacterial InfectionsBacterial Infections and MycosesInfectionsClostridium InfectionsBordetella InfectionsGram-Negative Bacterial InfectionsRespiratory Tract InfectionsRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

ToxoidsVaccinesBiological ProductsComplex Mixtures

Results Point of Contact

Title
Medical Director
Organization
Sanofi Pasteur Inc.

Study Officials

  • Medical Director

    Sanofi Pasteur Inc.

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 4
Allocation
NA
Masking
NONE
Purpose
PREVENTION
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 3, 2010

First Posted

June 4, 2010

Study Start

June 1, 2010

Primary Completion

March 1, 2016

Study Completion

September 1, 2016

Last Updated

April 28, 2022

Results First Posted

January 4, 2017

Record last verified: 2022-03

Data Sharing

IPD Sharing
Will share

Qualified researchers may request access to patient level data and related study documents including the clinical study report, study protocol with any amendments, blank case report form, statistical analysis plan, and dataset specifications. Patient level data will be anonymized and study documents will be redacted to protect the privacy of trial participants. Further details on Sanofi's data sharing criteria, eligible studies, and process for requesting access can be found at: https://vivli.org

Locations