Resistance Training in Patients With Chronic Obstructive Lung Disease (COPD): Whole Body Vibration Versus Conventional Resistance Training

NCT01135966 | Completed Phase 3

• 1 other identifier: 2010/157
• Study Type: interventional
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

Pulmonary rehabilitation has been emerged as a recommended standard of care for patients with chronic lung disease based on a growing body of scientific evidence. A set of evidence-based guidelines were published in American College of Chest Physicians (ACCP) and the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR). Since then, the published literature in pulmonary rehabilitation has increased substantially, and other societies have published important statements about pulmonary rehabilitation (eg, the American Thoracic Society and the European Respiratory Society). In patients with COPD, there is a strong scientific basis for implementing conventional resistance training (CRT) in addition to endurance training. Endurance training, such as walking, is a key component of pulmonary rehabilitation and improves in exercise tolerance and muscular endurance. However, this type of training may not reverse muscle weakness or atrophy. For that reason, strength training seems to be the optimum training modality to increase muscle mass and strength. Recently, Whole-Body-Vibration (WBV) training has been promoted as an alternative for resistance training on multigym equipment. In WBV training, the subject stands on a platform that generates vertical sinusoidal vibration, during which static and dynamic exercises can be performed. The present study is conducted to provide an answer on the following question: will a resistance training program, such as the whole body vibration, be even effective than a conventional resistance training program in patients with COPD.

Conditions

COPD

Keywords

COPD; Whole Body Vibration training; Conventional resistance training

Outcome Measures

Primary Outcomes (1)

• estimation of the change of 6 MWD before and after 12 weeks resistance training program (CRT versus WBV training)

  estimation of the change of 6 MWD (submaximal walking test)after a 12 week conventional resistance training program or after a 12 week whole body vibration training program

  before and after 12 weeks

Secondary Outcomes (7)

• changes in muscle strength (quadriceps force)after CRT or after WBV training in patients with COPD

  before and after 12 weeks

• changes in body composition after CRT or after WBV training in patients with COPD

  before and after 12 weeks

• changes in maximal exercise capacity after CRT or after WBV training in patients with COPD

  before and after 12 weeks

• changes in muscle force after CRT or after WBV training in patients with COPD

  before and after 12 weeks

• changes in Quality of life after CRT or after WBV training in patients with COPD

  beforer and after 12 weeks

Study Arms (2)

Conventional training

ACTIVE COMPARATOR

Behavioral: Conventional resistance training program

Whole body vibration training

EXPERIMENTAL

Behavioral: Whole body vibration resistance training program

Interventions

Conventional resistance training program BEHAVIORAL

Conventional resistance training program is followed.

Conventional training

Whole body vibration resistance training program BEHAVIORAL

WBV training on FITVIBE

Whole body vibration training

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with COPD candidate for pulmonary rehabilitation
• Men and female between 40 and 80 years of age
• Written informed consent to participate

You may not qualify if:

• Severe cardiac, neurological and orthopedic co-morbidity interfering with exercise training.
• Pacemaker
• Hip, knee of shoulder prosthesis or recently introduced spirals, metal pens, bolts or plates
• Uncontrolled diabetes, epilepsy or migraine
• Osteoporotic or metastatic fractures, acute hernia, discopathy, spondylitis

Sponsors & Collaborators

• University Hospital, Ghent: lead

Study Sites (1)

University Hospital Ghent

Ghent, Belgium

Location

Related Publications (1)

• Salhi B, Malfait TJ, Van Maele G, Joos G, van Meerbeeck JP, Derom E. Effects of Whole Body Vibration in Patients With COPD. COPD. 2015;12(5):525-32. doi: 10.3109/15412555.2015.1008693. Epub 2015 Aug 4.

  PMID: 26457458 DERIVED

Related Links

• website of University Hospital Ghent

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Eric Derom, MD, PhD

  University Hospital, Ghent

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 2, 2010
• First Posted: June 3, 2010
• Study Start: April 1, 2010
• Primary Completion: July 1, 2011
• Study Completion: November 1, 2011
• Last Updated: December 12, 2011

Record last verified: 2011-12

Locations

BE (1)