NCT01134289

Brief Summary

This study aims to compare the alternative current and the direct current signal changes of photoplethysmography between both feet during one side lumbar sympathetic block. The hypothesis is that signal changes occur earlier than other indices to decide whether it is successful following lumbar sympathetic block on only one-side.

Trial Health

55
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
25

participants targeted

Target at below P25 for phase_3

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2009

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2010

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

May 19, 2010

Completed
12 days until next milestone

First Posted

Study publicly available on registry

May 31, 2010

Completed
Last Updated

June 7, 2010

Status Verified

June 1, 2010

Enrollment Period

5 months

First QC Date

May 19, 2010

Last Update Submit

June 4, 2010

Conditions

Keywords

complex regional pain syndromelumbar sympathetic blockadephotoplethysmographydiagnostic lumbar sympathetic blockade

Outcome Measures

Primary Outcomes (1)

  • Index of sympathetic block

    change of slope of signals of the alternative current and the direct current from foot The baseline is defined as the point of surgical drap. The end of procedure is decided when the temperature of foot is increased more than 2 degrees from baseline within 20 minutes after local anesthetics injection

    1 minute at intervals from baseline through end of procedure

Secondary Outcomes (2)

  • skin temperature changes

    1 minute at intervals during procedure

  • electrocardiogram

    1 minute at intervals from baseline through end of procedure

Study Arms (2)

lumbar sympathetic block

ACTIVE COMPARATOR

Unilateral lumbar sympathetic blockade using chirocaine

Procedure: lumbar sympathetic block

contralateral side

NO INTERVENTION

Interventions

unilateral lumbar sympathetic block at L3 level using 0.2% chirocaine under C-arm fluoroscopy

Also known as: 0.25% bupivacaine (Chirocaine, Abbott, Elverum, Norway), C-arm (OEC 9800 plus, GE Medical Systems, Salt Lake City, UT), Chiba needle (Cook Inc., Bloomington, IN)
lumbar sympathetic block

Eligibility Criteria

Age19 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Physically examined for complex regional pain syndrome on lower extremity,
  • Scheduled for diagnostic lumbar sympathetic blockade.

You may not qualify if:

  • Graded as ASA 3 or higher,
  • Below 18 or above 70 years of age, or
  • Had any other contraindication for regional anesthesia.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Anesthesiology and Pain Medicine, Seoul National University Hospital

Seoul, 110744, South Korea

RECRUITING

MeSH Terms

Conditions

Complex Regional Pain Syndromes

Interventions

BupivacaineLevobupivacaine

Condition Hierarchy (Ancestors)

Autonomic Nervous System DiseasesNervous System DiseasesPeripheral Nervous System DiseasesNeuromuscular Diseases

Intervention Hierarchy (Ancestors)

AnilidesAmidesOrganic ChemicalsAniline CompoundsAmines

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NON RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 19, 2010

First Posted

May 31, 2010

Study Start

September 1, 2009

Primary Completion

February 1, 2010

Last Updated

June 7, 2010

Record last verified: 2010-06

Locations