Fetal Programming of Obesity
1 other identifier
observational
320
1 country
1
Brief Summary
The overall goal of this project is to understand how a mother's health at conception may influence her child's growth and development.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2010
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 2, 2010
CompletedFirst Submitted
Initial submission to the registry
May 25, 2010
CompletedFirst Posted
Study publicly available on registry
May 26, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2024
CompletedFebruary 14, 2025
January 1, 2025
8.3 years
May 25, 2010
February 13, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Child body composition
lean and fat mass of the child
24 months
Secondary Outcomes (5)
Child metabolism
24 months
Child development
24 months
Child dietary intake
24 months
Placenta gene expression
9 months
Placenta protein content
9 months
Study Arms (1)
Pregnant women
Eligibility Criteria
Healthy women
You may qualify if:
- healthy
- years of age or older
- second pregnancy, singleton
- conceived without fertility treatments
You may not qualify if:
- Preexisting medical conditions
- Sexually transmitted diseases
- Medical complications during pregnancy
- Medications during pregnancy known to influence fetal growth
- Smoking, alcohol drinking
- Excessive physical activity level which could affect the outcome of interest.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Arkansas Children's Nutrition Center
Little Rock, Arkansas, 72202, United States
Related Publications (11)
Crimmins MR, Hand M, Samuel H, Bellando J, Sims CR, Andres A, Sobik S. The Impact of Excessive Weight on Breastfeeding Intention, Initiation, and Duration. Breastfeed Med. 2023 Sep;18(9):688-695. doi: 10.1089/bfm.2023.0072.
PMID: 37729033DERIVEDGilley SP, Ruebel ML, Sims C, Zhong Y, Turner D, Lan RS, Pack LM, Piccolo BD, Chintapalli SV, Abraham A, Bode L, Andres A, Shankar K. Associations between maternal obesity and offspring gut microbiome in the first year of life. Pediatr Obes. 2022 Sep;17(9):e12921. doi: 10.1111/ijpo.12921. Epub 2022 Apr 27.
PMID: 35478493DERIVEDKracht CL, Redman LM, Casey PH, Krukowski RA, Andres A. Association between Home Environment in Infancy and Child Movement Behaviors. Child Obes. 2021 Mar;17(2):100-109. doi: 10.1089/chi.2020.0319. Epub 2021 Jan 20.
PMID: 33471594DERIVEDSaben JL, Sims CR, Piccolo BD, Andres A. Maternal adiposity alters the human milk metabolome: associations between nonglucose monosaccharides and infant adiposity. Am J Clin Nutr. 2020 Nov 11;112(5):1228-1239. doi: 10.1093/ajcn/nqaa216.
PMID: 32844207DERIVEDSims CR, Lipsmeyer ME, Turner DE, Andres A. Human milk composition differs by maternal BMI in the first 9 months postpartum. Am J Clin Nutr. 2020 Sep 1;112(3):548-557. doi: 10.1093/ajcn/nqaa098.
PMID: 32401302DERIVEDAllman BR, Diaz EC, Andres A, Borsheim E. Divergent Changes in Serum Branched-Chain Amino Acid Concentrations and Estimates of Insulin Resistance throughout Gestation in Healthy Women. J Nutr. 2020 Jul 1;150(7):1757-1764. doi: 10.1093/jn/nxaa096.
PMID: 32275314DERIVEDDiaz EC, Borsheim E, Shankar K, Cleves MA, Andres A. Prepregnancy Fat Free Mass and Associations to Glucose Metabolism Before and During Pregnancy. J Clin Endocrinol Metab. 2019 May 1;104(5):1394-1403. doi: 10.1210/jc.2018-01381.
PMID: 30496579DERIVEDPorter H, West DS, Cleves MA, Saylors ME, Andres A, Krukowski RA. Association Between Household Food Environment and Excessive Gestational Weight Gain. J Womens Health (Larchmt). 2018 Aug;27(8):1064-1070. doi: 10.1089/jwh.2017.6552. Epub 2018 Apr 5.
PMID: 29620954DERIVEDKrukowski RA, West DS, DiCarlo M, Cleves MA, Saylors ME, Andres A. Association of Gestational Weight Gain Expectations and Advice on Actual Weight Gain. Obstet Gynecol. 2017 Jan;129(1):76-82. doi: 10.1097/AOG.0000000000001780.
PMID: 27926649DERIVEDKrukowski RA, West DS, DiCarlo M, Shankar K, Cleves MA, Saylors ME, Andres A. Are early first trimester weights valid proxies for preconception weight? BMC Pregnancy Childbirth. 2016 Nov 21;16(1):357. doi: 10.1186/s12884-016-1159-6.
PMID: 27871260DERIVEDKrukowski RA, West D, DiCarlo M, Shankar K, Cleves MA, Tedford E, Andres A. A Behavioral Intervention to Reduce Excessive Gestational Weight Gain. Matern Child Health J. 2017 Mar;21(3):485-491. doi: 10.1007/s10995-016-2127-5.
PMID: 27449652DERIVED
Biospecimen
Blood, urine, stool, human milk, placenta, cord blood and umbilical cord may be collected from study participants.
Study Officials
- PRINCIPAL INVESTIGATOR
Aline Andres, PhD, RD
Arkansas Children's Nutrition Center
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 25, 2010
First Posted
May 26, 2010
Study Start
April 2, 2010
Primary Completion
August 1, 2018
Study Completion
November 1, 2024
Last Updated
February 14, 2025
Record last verified: 2025-01