Sleep, Breathing and Psychomotor Performance at Altitude: A Physiologic Study in Healthy Subjects

NCT01130948 | Completed DMC

• 1 other identifier: 2010-0054/1
• Study Type: interventional
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the effect of altitude exposure on sleep, breathing and psychomotor performance in healthy subjects.

Conditions

Healthy Men

Keywords

hypoxia; altitude; sleep; sleep apnea; periodic breathing; vigilance; psychomotor; endothelial function

Outcome Measures

Primary Outcomes (2)

• apnea/hypopnea index

  day 1-4 at altitude

• Reaction time

  psychomotor vigilance test reaction time

  day 1-4 at altitude

Secondary Outcomes (3)

• Psychomotor vigilance

  day 1-4 at altitude

• sleep quality

  day 1-4 at altitude

• arterial applanation tonometry

  day 1-4 at altitude

Interventions

altitude exposure OTHER

exposure to 490m, 1700m and 2590m

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• healthy men
• residence at \<800m

You may not qualify if:

• any active disease requiring treatment
• requirement for regular use of medication
• smoking, regular intake of alcohol or drugs
• body mass index \<18 or \>30 kg/m2
• previous intolerance of moderate altitude (\<3000m)

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University Hospital of Zurich, Pulmonary Division

Zurich, CH-8091, Switzerland

Location

Related Publications (6)

• Latshang TD, Lo Cascio CM, Stowhas AC, Grimm M, Stadelmann K, Tesler N, Achermann P, Huber R, Kohler M, Bloch KE. Are nocturnal breathing, sleep, and cognitive performance impaired at moderate altitude (1,630-2,590 m)? Sleep. 2013 Dec 1;36(12):1969-76. doi: 10.5665/sleep.3242.

  PMID: 24293773 BACKGROUND

• Stadelmann K, Latshang TD, Tarokh L, Lo Cascio CM, Tesler N, Stoewhas AC, Kohler M, Bloch KE, Huber R, Achermann P. Sleep respiratory disturbances and arousals at moderate altitude have overlapping electroencephalogram spectral signatures. J Sleep Res. 2014 Aug;23(4):463-8. doi: 10.1111/jsr.12131. Epub 2014 Feb 19.

  PMID: 24552365 BACKGROUND

• Ayers L, Stoewhas AC, Ferry B, Latshang TD, Lo Cascio CM, Sadler R, Stadelmann K, Tesler N, Huber R, Achermann P, Bloch KE, Kohler M. Circulating levels of cell-derived microparticles are reduced by mild hypobaric hypoxia: data from a randomised controlled trial. Eur J Appl Physiol. 2014 May;114(5):1067-73. doi: 10.1007/s00421-014-2837-6. Epub 2014 Feb 11.

  PMID: 24514947 BACKGROUND

• Stadelmann K, Latshang TD, Lo Cascio CM, Tesler N, Stoewhas AC, Kohler M, Bloch KE, Huber R, Achermann P. Quantitative changes in the sleep EEG at moderate altitude (1630 m and 2590 m). PLoS One. 2013 Oct 22;8(10):e76945. doi: 10.1371/journal.pone.0076945. eCollection 2013.

  PMID: 24167552 BACKGROUND

• Stowhas AC, Latshang TD, Lo Cascio CM, Lautwein S, Stadelmann K, Tesler N, Ayers L, Berneis K, Gerber PA, Huber R, Achermann P, Bloch KE, Kohler M. Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. PLoS One. 2013 Aug 1;8(8):e70081. doi: 10.1371/journal.pone.0070081. Print 2013.

  PMID: 23936377 BACKGROUND

• Stadelmann K, Latshang TD, Lo Cascio CM, Clark RA, Huber R, Kohler M, Achermann P, Bloch KE. Impaired postural control in healthy men at moderate altitude (1630 m and 2590 m): data from a randomized trial. PLoS One. 2015 Feb 27;10(2):e0116695. doi: 10.1371/journal.pone.0116695. eCollection 2015.

  PMID: 25723529 DERIVED

MeSH Terms

Conditions

Hypoxia; Sleep Apnea Syndromes

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Study Officials

• Konrad E Bloch, Prof. MD

  University Hospital Zurich, Pulmonary Division

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2010
• First Posted: May 26, 2010
• Study Start: May 1, 2010
• Primary Completion: October 1, 2010
• Study Completion: October 1, 2010
• Last Updated: May 20, 2014

Record last verified: 2014-05

Locations

CH (1)