The Effects of Plant Bioactives on Platelet Function
1 other identifier
interventional
15
1 country
1
Brief Summary
Consumption of a diet rich in fruit and vegetables is associated with a reduced risk of cardiovascular disease and the protective effect may be due to polyphenolic compounds contained within these foods. The mechanism by which polyphenols exert this effect is not clearly understood but research has focused on their potential to affect platelet function. The purpose of this study is to quantify the anti-clotting activity of a range of plant food extracts and component compounds.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable healthy
Started Jun 2010
Typical duration for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 24, 2010
CompletedFirst Posted
Study publicly available on registry
May 25, 2010
CompletedStudy Start
First participant enrolled
June 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2011
CompletedMarch 6, 2013
March 1, 2013
1 year
May 24, 2010
March 5, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Identification of flavonoids that exert a significant anti-clotting effect
within 4hours
Study Arms (1)
Ex-vivo treatment of platelets
EXPERIMENTALEx-vivo treatment of platelets
Interventions
Ex-vivo treatment of platelets with a range of flavonoids
Eligibility Criteria
You may qualify if:
- Males and females
- Aged 18 - 65 years.
- BMI \> 19.5 and \< 35
- Non-smokers
You may not qualify if:
- Pregnancy or have been pregnant within the last 12 months
- Parallel participation in another research project which involves dietary intervention
- Participation in another research project which has involved blood sampling within the last four months unless the total amount of combined blood from both studies does not exceed 470 mls.
- Has donated or intends to donate blood within 16 weeks prior to during the Study period.
- Depressed or elevated blood pressure measurements (\<90/50 or 95/50 if symptomatic or \>160/100)
- Any person related to or living with any member of the study team
- Diabetics
- Taking regular prescribed and/or non-prescribed medication (excluding oral contraceptive and HRT).
- Known bleeding disorders.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Quadram Institute Biosciencelead
- European Unioncollaborator
Study Sites (1)
Institute of Food Research
Norwich, Norfolk, NR4 7UA, United Kingdom
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Paul Kroon, phD
Quadram Institute Bioscience
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 24, 2010
First Posted
May 25, 2010
Study Start
June 1, 2010
Primary Completion
June 1, 2011
Study Completion
June 1, 2011
Last Updated
March 6, 2013
Record last verified: 2013-03