Role of CCL2 in Alcoholic Liver Diseases

NCT01128010 | Completed

• 1 other identifier: DD-CCL2
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Immune dysregulations, including cytokines and chemokines secretions occurs in alcoholic liver disease. Serum levels and liver expression of CCL2 are increased in patients with alcoholic hepatitis but the role of this chemokine in the pathogenesis of alcoholic liver disease is nevertheless unknown. The aim of the study is to analyze plasma level and liver expression of CCL2 and their relation with liver disease severity and inflammatory infiltrate in our cohort of alcoholic patients. We studied also the association between -2518 CCL2 polymorphism and the severity of alcoholic liver disease.

Conditions

Alcoholic Liver Disease

Study Arms (2)

alcoholic liver disease

alcoholic liver disease patients undergoing a transjugular liver biopsy in our institution

controls

Healthy controls patients recruited from the Occupational Medicine Department during a routine physical examination

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Consecutive patients undergoing transjugular liver biopsy for alcoholic liver disease will be include in the study to measure plasma levels and hepatic expression of CCL2. We determine also the rs1024611 polymorphism of these patients. All these parameters are correlated to severity of the disease. The frequency of the presence of this polymorphism was also compared to a population of healthy subjects.

You may qualify if:

• Excess alcohol intake
• Abnormality of liver biopsy compatible with alcoholic aetiology
• Caucasian ethnicity

You may not qualify if:

• Presence of any other chronic liver disease
• Caucasian ethnicity
• presence of a disease

Sponsors & Collaborators

• Erasme University Hospital: lead

MeSH Terms

Conditions

Liver Diseases, Alcoholic

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Alcohol-Induced Disorders; Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 20, 2010
• First Posted: May 21, 2010
• Last Updated: May 21, 2010

Record last verified: 2002-12