Training Interventions and Genetics of Exercise Response (TIGER)
TIGER
1 other identifier
observational
3,773
1 country
2
Brief Summary
Obesity established in adolescence strongly predicts obesity for the remainder of adult life, and the consequences are potentially devastating, characterized by a lifelong burden of co-morbid conditions and depression. This study will provide an exposure to physical activity that is designed to teach and empower sedentary college age individuals to become physically active. The investigators will evaluate whether such exposure can result in lasting changes in exercise behavior and body composition. The study will also provide a better understanding of the genetic factors that influence persistence in an exercise program and that influence whole body response to exercise training. Altering the course of obesity in adolescence has the potential to reduce the adult prevalence of obesity and consequently attenuate the public health burden of overweight and obesity in the investigators population.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2010
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 19, 2010
CompletedFirst Posted
Study publicly available on registry
May 21, 2010
CompletedStudy Start
First participant enrolled
July 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2017
CompletedNovember 13, 2017
November 1, 2017
5.8 years
May 19, 2010
November 8, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Exercise Response
Physiologic variables measured pre and post exercise intervention
15 Weeks
Gene Expression
Changes in the expression of genes following exercise training
15 Weeks
Adherence
Retention versus drop-out from the exercise protocol
15 Weeks
Genotyping
Characterization of candidate genes related to exercise response
15 Weeks
Study Arms (3)
Low Commitment
Group 1 participants will take a 1-credit hour course that involves exercise training only.
High Commitment
Group 2 participants will take a 3-credit hour course that involves exercise training plus an online cognitive component that provides information on fitness and health topics and includes quizzes and other written course work
Non-Exercise
Group 3 participants will take the cognitive component of the formal course but will not partake in the formalized exercise program for a period of 35 weeks.
Interventions
40 minutes, 3 times a week for 35 weeks.
Provide general information about health and fitness
Eligibility Criteria
The target for phase 2 of the TIGER study is a student, age 18-30, who has not engaged in moderate physical activity more than 30 minutes per week for the previous 30 days and who is not actively limiting his/her caloric intake by dieting. It is planned to enroll a total of 3,200 subjects from student populations at the University of Houston (UH) and the University of Alabama at Birmingham (UAB) and representative of the race/ethnicity distribution of the respective campuses. Approximately 2,400 subjects will participate in the exercise protocol (600/yr for four years). A control group (200/yr for four years) will also be recruited that will not participate in the formal exercise for at least 35 weeks, but will be given the option of completing the formal exercise program after that time.
You may qualify if:
- years old
- Healthy
- sedentary at baseline
You may not qualify if:
- any medical or physical contra-indication for exercise (as indicated by the subject's physician) and/or
- any known metabolic or endocrine disorder associated with alterations in body composition (e.g., lipodystrophy).
- Refusal to consent for the use of their DNA for genetic research.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
University of Houston
Houston, Texas, 77005, United States
Biospecimen
Blood components and DNA
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Molly Bray, PhD
University of Alabama at Birmingham
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Professor of Public Health
Study Record Dates
First Submitted
May 19, 2010
First Posted
May 21, 2010
Study Start
July 1, 2010
Primary Completion
May 1, 2016
Study Completion
November 1, 2017
Last Updated
November 13, 2017
Record last verified: 2017-11