Improving Metoclopramide Prescribing Practices at Penn Through a Physician-targeted Intervention

NCT01126034 | Completed

• 1 other identifier: UPenn - 802142
• Study Type: interventional
• Target: 85
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators hypothesized that: 1\) an intervention targeted at the prescribing physician would increase the rate of a metoclopramide discontinuation among patients prescribed the medication for questionable or unclear indications; and 2) the discontinuation would be durable.

Conditions

Gastroesophageal Reflux Disease; Diabetic Gastroparesis

Keywords

Metoclopramide; Randomized Controlled Trial

Outcome Measures

Primary Outcomes (1)

• Discontinuation of metoclopramide therapy

  Twelve weeks after the intervention period, we searched the medical records of patients in the intervention and non-intervention groups to determine whether discontinuation of metoclopramide therapy had taken place.

  12 weeks after intervention period

Study Arms (2)

intervention

EXPERIMENTAL

Physicians in the intervention group were mailed a written feedback letter regarding their patients who were prescribed questionable metoclopramide therapy. Non-intervention providers received no letter. The letter consisted of the following components: 1. The name and medical record # of the patients involved 2. Information regarding the metoclopramide prescription: dates, dosage, indication recorded, and the duration of therapy 3. A reminder of the adverse effect of long-term metoclopramide therapy 4. A recommendation to consider having the patient undergo a trial of metoclopramide discontinuation if appropriate, and documentation of a discussion of risk and benefits of metoclopramide therapy with patients 5. A request that the physician document the discontinuation trial in the electronic medical record

Other: intervention letter

non-intervention

NO INTERVENTION

No intervention letters were sent to subjects in this arm

Interventions

intervention letter OTHER

Physicians in the intervention group were mailed a written feedback letter regarding their patients who were prescribed questionable metoclopramide therapy. Non-intervention providers received no letter. The letter consisted of the following components: 1. The name and medical record # of the patients involved 2. Information regarding the metoclopramide prescription: dates, dosage, indication recorded, and the duration of therapy 3. A reminder of the adverse effect of long-term metoclopramide therapy 4. A recommendation to consider having the patient undergo a trial of metoclopramide discontinuation if appropriate, and documentation of a discussion of risk and benefits of metoclopramide therapy with patients 5. A request that the physician document the discontinuation trial in the electronic medical record

intervention

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Physicians at University of Pennsylvania Health System who ordered an active metoclopramide prescription with a questionable indication.

You may not qualify if:

• Physicians-in-training (e.g., residents, fellows)
• Physicians how were investigators on this study
• Physicians serving on the the University of Pennsylvania Drug Use and Effects Committee or Information Technology Oversight Board

Sponsors & Collaborators

• University of Pennsylvania: lead

Study Sites (1)

University of Pennsylvania Center for Clinical Epidemiology and Biostatistics

Philadelphia, Pennsylvania, 19104, United States

Location

MeSH Terms

Conditions

Gastroesophageal Reflux

Condition Hierarchy (Ancestors)

Esophageal Motility Disorders; Deglutition Disorders; Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases

Study Officials

• Yu-Xiao Yang, MD, MSCE

  University of Pennsylvania

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 17, 2010
• First Posted: May 19, 2010
• Study Start: March 1, 2007
• Primary Completion: April 1, 2008
• Study Completion: April 1, 2008
• Last Updated: December 4, 2015

Record last verified: 2015-12

Locations

US (1)