Case-control Study on Matrix Metalloproteinase Levels in Tissue in Patients With Keloid Scar

NCT01125137 | Completed DMC

• 1 other identifier: IRB #5890
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Purpose: To compare the levels of matrix metalloproteinase-1 (MMP-1), MMP-8, MMP-13 and tissue inhibitor of metalloproteinases (TIMPs) in keloid skin tissue with normal skin in the same patient and with normal discarded skin tissue (control). The investigators aim to correlate between levels of MMPs in patients with keloid scarring in comparison with normal and discarded tissue.

Conditions

Keloid

Keywords

Keloid; MMP; Matrix metalloproteinase; dermatology

Outcome Measures

Primary Outcomes (1)

• Correlate the level of matrix metalloproteinases in keloid tissue versus normal skin

  One time office visit for keloid excision, there will be no follow up visits for patient. Keloid tissue will be analyzed in Henry Ford Hospital laboratory after excision.

Study Arms (1)

Biopsy

EXPERIMENTAL

Procedure: Removal of Keloid

Interventions

Removal of Keloid PROCEDURE

Keloid will be excised by Henry Ford Hospital Dermatologist, Dermatosurgeon or Plastic Surgeon.

Biopsy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Be at least 18 years old;
• Have a keloid and accept to have it excised;
• Be able to understand the requirements for the study, the risks involved and are able to sign the informed consent form;
• Agree to follow and undergo all study-related procedures

You may not qualify if:

• Subjects will be excluded if any of the following apply:
• Women who are lactating, pregnant, or planning to become pregnant;
• Patients with a recent history of serious systemic disease;
• Patients who are receiving treatment for the keloid or have received treatment in the past 1 year.
• Any reason the investigator feels the patient should not participate in the study.

Sponsors & Collaborators

• Henry Ford Health System: lead

Study Sites (1)

Henry Ford Hospital Dermatology Dept. 3031 West Grand Blvd, Suite 800

Detroit, Michigan, 48202, United States

Location

MeSH Terms

Conditions

Keloid

Condition Hierarchy (Ancestors)

Collagen Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Cicatrix; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Iltefat Hamzavi, M.D.

  Henry Ford Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dermatologist

Study Record Dates

• First Submitted: February 2, 2010
• First Posted: May 18, 2010
• Study Start: February 1, 2010
• Primary Completion: January 1, 2011
• Study Completion: January 1, 2011
• Last Updated: April 30, 2024

Record last verified: 2024-04

Locations

US (1)