NCT01121055

Brief Summary

Many patients undergoing flexible bronchoscopy (FB) experience anxiety and discomfort during the procedure. The investigators want to evaluate whether an additional Lorazepam premedication would improve patient satisfaction for FB.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
372

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started Mar 2010

Shorter than P25 for phase_4

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2010

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

May 9, 2010

Completed
3 days until next milestone

First Posted

Study publicly available on registry

May 12, 2010

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2010

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2010

Completed
Last Updated

May 31, 2010

Status Verified

May 1, 2010

Enrollment Period

5 months

First QC Date

May 9, 2010

Last Update Submit

May 27, 2010

Conditions

Keywords

Fiberoptic BronchoscopyPatientSatisfactionLorazepam

Outcome Measures

Primary Outcomes (1)

  • patient satisfaction

    within 24 hr of bronchoscopy

Secondary Outcomes (1)

  • relationship between patient satisfaction and sleep quality, anxiety level

    24hr before and after bronchoscopy

Study Arms (2)

Control

PLACEBO COMPARATOR

Placebo 1T by mouth (po) at night one day before FB and placebo 1T po 30min before the FB

Drug: Control

Lorazepam

EXPERIMENTAL

Lorazepam 0.5mg po at night one day before FB and Lorazepam 1mg po 30min before the FB

Drug: Lorazepam

Interventions

Lorazepam 0.5mg po at night one day before FB and Lorazepam 1mg po 30min before the FB

Lorazepam

Placebo 1T po at night one day before FB and placebo 1T po 30min before the FB

Control

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adult patients (aged 18 years or older) admitted to the Respiratory Department

You may not qualify if:

  • outpatient procedures
  • therapeutic bronchoscopy
  • expected operation or discharge within 24 hours after the FB
  • sedative premedication
  • endotracheal intubation with mechanical ventilation
  • inability to speak Korean

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Seoul National University Hospital

Seoul, 110-744, South Korea

RECRUITING

MeSH Terms

Conditions

Personal Satisfaction

Interventions

Lorazepam

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

BenzodiazepinonesBenzodiazepinesBenzazepinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Study Officials

  • Seok-Chul Yang, MD

    Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine

    STUDY CHAIR

Central Study Contacts

Seok-Chul Yang, MD, PhD

CONTACT

Jong Sun Park, MD

CONTACT

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 9, 2010

First Posted

May 12, 2010

Study Start

March 1, 2010

Primary Completion

August 1, 2010

Study Completion

December 1, 2010

Last Updated

May 31, 2010

Record last verified: 2010-05

Locations