NCT01120860

Brief Summary

The primary purpose of this study is to apply state-of-the-art Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) techniques to measure changes over time in the brain.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
67

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Nov 2002

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2002

Completed
7.5 years until next milestone

First Submitted

Initial submission to the registry

May 7, 2010

Completed
4 days until next milestone

First Posted

Study publicly available on registry

May 11, 2010

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2011

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2011

Completed
Last Updated

February 28, 2017

Status Verified

February 1, 2017

Enrollment Period

8.7 years

First QC Date

May 7, 2010

Last Update Submit

February 24, 2017

Conditions

Age-related Cognitive Decline

Keywords

Cognitive AgingApolipoproteins EMagnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

  • flight simulator performance summary score

    z-score composite of executing ATC communications, avoiding traffic, monitoring engine malfunctions, visual approach and landing

    yearly for up to 6 years

Secondary Outcomes (2)

  • CogScreen-AE

    yearly

  • Salthouse processing speed measures

    yearl

Interventions

MRIDEVICE

MRI - routine imaging sequences, designed for anatomical quantification

Eligibility Criteria

Age45 Years - 100 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

active healthy pilots

You may qualify if:

  • Subjects will be included if they have participated in the protocol "Age-Related Longitudinal Changes in Aviator Performance" and agree to participate in this protocol.

You may not qualify if:

  • Subjects will be excluded if they currently have a major neurological disease, unstable/untreated medical disease (such as untreated hypertension).
  • In consideration of the magnetic fields in which subjects will be placed for the MR scanning, we will also exclude subjects who are unable to safely and comfortably complete the scanning session. This includes individuals who are wearing any metal prosthesis or who have cardiac pacemakers or any other nonremovable metal objects.
  • Subjects reporting a history of severe claustrophobia or poorly controlled back pain will be excluded because it is unlikely they could comfortably remain still in the MRI scanner for the duration of the scan.
  • In addition, subjects who do not fit in the apparatus will also be excluded.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

VA Palo Alto Health Care System

Palo Alto, California, 94304, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

frozen genomic DNA

Study Officials

  • Joy Taylor

    Stanford University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Clinical Professor (affiliated), Psychiatry & Behavioral Sciences

Study Record Dates

First Submitted

May 7, 2010

First Posted

May 11, 2010

Study Start

November 1, 2002

Primary Completion

July 1, 2011

Study Completion

July 1, 2011

Last Updated

February 28, 2017

Record last verified: 2017-02

Locations

US(1)