Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis
1 other identifier
observational
40
1 country
1
Brief Summary
Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing. However, the blood flow from these grafts "competes" with flow through the natural coronary artery. This may contribute to grafts narrowing with time. This protocol aims to determine the pressure changes responsible for this effect. This could improve our understanding of why some grafts last longer than others.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2010
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2010
CompletedFirst Submitted
Initial submission to the registry
May 5, 2010
CompletedFirst Posted
Study publicly available on registry
May 6, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2019
CompletedFebruary 8, 2017
February 1, 2017
9.9 years
May 5, 2010
February 6, 2017
Conditions
Keywords
Eligibility Criteria
Patients with previous bypass grafts undergoing angiography/ angioplasty who meet stduy criteria
You may qualify if:
- Patients with previous coronary artery bypass grafts undergoing coronary angiography and graft restudy
You may not qualify if:
- Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure
- Unable to consent
- Contraindications to adenosine
- Contraindications to cardiac MRI
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Imperial College NHS Trust
London, United Kingdom
Study Officials
- PRINCIPAL INVESTIGATOR
Justin E Davies, MRCP PhD
Imperial College London
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 5, 2010
First Posted
May 6, 2010
Study Start
January 1, 2010
Primary Completion
December 1, 2019
Study Completion
December 1, 2019
Last Updated
February 8, 2017
Record last verified: 2017-02