Activity of Inspiratory Muscles With the Use of Positive Pressure in Patients With Chronic Obstructive Pulmonary Disease

NCT01111487 | Completed

• 1 other identifier: 09-500
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 3

Brief Summary

The objective is to evaluate whether the use of expiratory positive airway pressure (EPAP) reduces the electrical activity of the sternocleidomastoid muscle and enhances the action of the muscle in the patient parasternal ported from Chronic Obstructive Pulmonary Disease. Noting also, if the set pressure level (10 or 15 cmH2O) affects this relationship.

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Keywords

COPD; Electromyography; Inspiratory muscles

Outcome Measures

Primary Outcomes (1)

• Electromyographic activity of muscles and sternocleidomastoid parasternal

  An average baseline, before the use of expiratory positive airway pressure (EPAP) to be compared with two-mediated during the 20 minutes of application of EPAP and 10 minutes after its removal.

  20 minutes

Study Arms (2)

Group I

ACTIVE COMPARATOR

This group will use a pressure level of 10 cmH2O.

Device: Expiratory positive airway pressure (EPAP) by face mask.

Group II

ACTIVE COMPARATOR

This group will use a pressure level of 15 cmH2O.

Device: Expiratory positive airway pressure (EPAP) by face mask.

Interventions

Expiratory positive airway pressure (EPAP) by face mask. DEVICE

Implementation of the EPAP as group pressure, 10 or 15 cmH2O, for 20 minutes then evaluated the electromyographic activity of muscles and sternocleidomastoid parasternal the tenth and twentieth minutes of your application.

Also known as: PEP-mask

Group I; Group II

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of COPD in stage II or III according to classification of the Global Initiative for Chronic Obstructive Lung Disease (GOLD);
• Signing the consent form;

You may not qualify if:

• Individuals would use artificial airway;
• Hemodynamic instability;
• Body mass index (BMI) above the values considered as obese (\> 30Kg/m2).

Sponsors & Collaborators

• Hospital de Clinicas de Porto Alegre: lead

Study Sites (3)

HCPA - Hospital of Clinicas of Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

Location

Federal University of Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, 90040-060, Brazil

Location

University of Santa Cruz do Sul

Santa Cruz do Sul, Rio Grande do Sul, 96815-900, Brazil

Location

Related Publications (8)

• Legrand A, Majcher M, Joly E, Bonaert A, Gevenois PA. Neuromechanical matching of drive in the scalene muscle of the anesthetized rabbit. J Appl Physiol (1985). 2009 Sep;107(3):741-8. doi: 10.1152/japplphysiol.91320.2008. Epub 2009 Jul 16.

  PMID: 19608926 BACKGROUND

• Yokoba M, Abe T, Katagiri M, Tomita T, Easton PA. Respiratory muscle electromyogram and mouth pressure during isometric contraction. Respir Physiol Neurobiol. 2003 Aug 14;137(1):51-60. doi: 10.1016/s1569-9048(03)00092-2.

  PMID: 12871677 BACKGROUND

• Yan S, Kaminski D, Sliwinski P. Inspiratory muscle mechanics of patients with chronic obstructive pulmonary disease during incremental exercise. Am J Respir Crit Care Med. 1997 Sep;156(3 Pt 1):807-13. doi: 10.1164/ajrccm.156.3.9702104.

  PMID: 9309997 RESULT

• Hudson AL, Gandevia SC, Butler JE. The effect of lung volume on the co-ordinated recruitment of scalene and sternomastoid muscles in humans. J Physiol. 2007 Oct 1;584(Pt 1):261-70. doi: 10.1113/jphysiol.2007.137240. Epub 2007 Aug 9.

  PMID: 17690147 RESULT

• CAMPBELL EJ. The role of the scalene and sternomastoid muscles in breathing in normal subjects; an electromyographic study. J Anat. 1955 Jul;89(3):378-86. No abstract available.

  PMID: 13251968 RESULT

• Levine S, Nguyen T, Friscia M, Zhu J, Szeto W, Kucharczuk JC, Tikunov BA, Rubinstein NA, Kaiser LR, Shrager JB. Parasternal intercostal muscle remodeling in severe chronic obstructive pulmonary disease. J Appl Physiol (1985). 2006 Nov;101(5):1297-302. doi: 10.1152/japplphysiol.01607.2005. Epub 2006 Jun 15.

  PMID: 16777998 RESULT

• Lien TC, Wang JH, Chang MT, Kuo CD. Comparison of BiPAP nasal ventilation and ventilation via iron lung in severe stable COPD. Chest. 1993 Aug;104(2):460-6. doi: 10.1378/chest.104.2.460.

  PMID: 8339634 RESULT

• van der Schans CP, de Jong W, de Vries G, Kaan WA, Postma DS, Koeter GH, van der Mark TW. Effects of positive expiratory pressure breathing during exercise in patients with COPD. Chest. 1994 Mar;105(3):782-9. doi: 10.1378/chest.105.3.782.

  PMID: 8131541 RESULT

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Sérgio S Menna Barreto, Dr

  Hospital of Clinicas of Porto Alegre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Post graduation

Study Record Dates

• First Submitted: April 26, 2010
• First Posted: April 27, 2010
• Study Start: November 1, 2009
• Primary Completion: August 1, 2011
• Study Completion: September 1, 2011
• Last Updated: September 27, 2011

Record last verified: 2011-09

Locations

BR (3)