Study of Human Leukocyte Antigen (HLA) Polymorphisms in Patients With Rheumatoid Arthritis

NCT01111357 | Completed

• 1 other identifier: 09/B/02
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Rheumatoid arthritis (RA), affects between 0.3% and 1.0% of the population, it can lead to progressive joint destruction and severe disability. To date, two RA genetic susceptibility factors have been identified: HLA-DRB1-SE (Shared epitope) and PTPN22 620W alleles. The predictive value of the alleles for diagnosis of RA was previously investigated in cohorts of caucasians patients with early unclassified arthritis that showed restrained association between RA and HLA-SE. Despite the contribution of HLA to the overall genetic risk has been estimated to range from 30% to 50%, it has never been studied in the French west-Indian population.

Conditions

Rheumatoid Arthritis

Keywords

Rheumatoid Arthritis; Rheumatoid Arthritis according to ACR criteria of diagnosis

Outcome Measures

Primary Outcomes (1)

• Difference of distribution of HLA alleles in patients and in healthy controls

  1 day

Secondary Outcomes (3)

• The association between the different HLA alleles among French West-Indian RA patients and the autoantibodies production.

  1 day

• The association between the different HLA alleles among French West-Indian RA patients and the radiological damage.

  1 day

• The association between the different HLA alleles among French West-Indian RA patients and the response to therapy

  1 day

Interventions

Collect of 10 ml of peripheric blood for DNA extraction BIOLOGICAL

After signed written consent, all patients have a clinic exam in order to assess the presence of eligibility criteria (Patient with Rheumatoid Arthritis that fulfil the ACR criteria of diagnosis)

Also known as: Rheumatoid Arthritis, French West-Indian Patients with Rheumatoid Arthritis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Residents of Martinique with at least 3 African-Caribbean grandparents

You may qualify if:

• Diagnosis of Rheumatoid Arthritis according to ACR criteria
• Come from French West Indies (At least 3 grandparents are African-Caribbean)
• Sign written informed consent

You may not qualify if:

• Minor
• Patient with no Rheumatoid Arthritis according to ACR criteria
• Patient does not agree for a genetic study
• For the control
• Blood donor
• Sign written informed consent
• Patient with no Rheumatoid Arthritis according to ACR criteria
• Come from French West Indies (At least 3 grandparents are African-Caribbean)
• Minor
• Patient does not agree for a genetic study

Sponsors & Collaborators

• University Hospital Center of Martinique: lead

Study Sites (1)

Service de rhumatologie CHU de Fort-de-France

Fort-de-France, 97261, Martinique

Location

Biospecimen

Retention: SAMPLES WITH DNA

whole blood : collect of 10 ml of peripheric blood

MeSH Terms

Conditions

Arthritis, Rheumatoid

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Georges JEAN-BAPTISTE, Professor of medecine

  CHU de Fort-de-France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 29, 2010
• First Posted: April 27, 2010
• Study Start: February 1, 2010
• Primary Completion: August 1, 2010
• Study Completion: August 1, 2010
• Last Updated: December 21, 2010

Record last verified: 2010-04

Locations

MA (1)