NCT01110109

Brief Summary

In this study, subjects meeting criteria will be enrolled and randomized to one of two different suctioning schemes, either continuous or intermittent. Accumulated secretions will be collected above the cuff on the breathing tube by one of the two methods depending on which group the subject is randomized into. Secretions will continue to be collected at predetermined periods of time for the duration of surgery in order to characterize the pH and volume as well as the micro-organism content.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
48

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Apr 2010

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2010

Completed
21 days until next milestone

First Submitted

Initial submission to the registry

April 22, 2010

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 26, 2010

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2010

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2010

Completed
Last Updated

October 26, 2010

Status Verified

October 1, 2010

Enrollment Period

5 months

First QC Date

April 22, 2010

Last Update Submit

October 25, 2010

Conditions

Keywords

AdultSurgeryEndotracheal TubeVentilatorPneumoniaSuctioning

Study Arms (2)

Continuous Suctioning

Anesthesia staff will suction secretions continuously at 20 mmHg with a safety stop of 5 seconds every 30 minutes.

Intermittent Suctioning

Anesthesia staff will suction secretions intermittently using an intermittent suction regulator. The regulator will be set to suction at 100-150 mmHg. The regulator has a preset cycle of intermittent suctioning for 15 seconds with an 8 second pause.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Adults undergoing surgery requiring intubation using the TaperGuard EVAC Endotracehal Tube

You may qualify if:

  • Surgery to be performed with expected time between tracheal intubation and extubation of at least two hours, but no longer than 12 hours
  • Intubation planned with TaperGuard EVAC Endotracheal Tube
  • Age of 18 or older
  • Ability to provide informed consent

You may not qualify if:

  • Presence of tracheostomy
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Tulane University Hospital

New Orleans, Louisiana, 70112, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Suction secretions

MeSH Terms

Conditions

Pneumonia, Ventilator-AssociatedPneumonia

Condition Hierarchy (Ancestors)

Healthcare-Associated PneumoniaCross InfectionInfectionsRespiratory Tract InfectionsLung DiseasesRespiratory Tract DiseasesIatrogenic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Francis A Rosinia, M.D.

    Tulane University Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

April 22, 2010

First Posted

April 26, 2010

Study Start

April 1, 2010

Primary Completion

September 1, 2010

Study Completion

October 1, 2010

Last Updated

October 26, 2010

Record last verified: 2010-10

Locations