Improving Clinical PET/CT Image Quality in Retrospectively Reconstructed Breath-Hold Images

NCT01109953 | Terminated

• 1 other identifier: 10-054
• Study Type: observational
• Target: 6
• Locations: 1 country
• Sites: 1

Brief Summary

The patient has been referred for an FDG PET/CT scan. FDG is a form of sugar that contains a small amount of radioactivity; it is used to see the size and possible spread of cancer in the body. Pictures of the body are taken on a machine called a PET/CT scanner. The purpose of this current study is to see if we, the investigators, can take clearer pictures of the tumor than we could with our routine scan method. This would allow us to better see how FDG is picked up by the tumor. PET/CT is presently one of the best tools for detecting cancer and determining its spread in the body. However, due to breathing motion, PET and CT images may become blurred and the location of the tumor on CT and PET images may not match. We have developed a new method that enables us to reduce image blurring and to measure the tumor more accurately on PET images. In this study we want to compare two kinds of images: those from the standard PET/CT scan, and the PET/CT scan pictures taken with our new method. If successful, we may use this new method for clinical routine in the future.

Conditions

Lung Cancer

Keywords

Lung; PET/CT scan; 10-054

Outcome Measures

Primary Outcomes (1)

• To determine if our breath-hold acquisition technique can be implemented in whole-body PET/CT scans.

  Because PET events not satisfying the breathing amplitude selection criteria will be dropped off the final image set, it will be necessary to increase the acquisition time for the FOV's covering the thorax area from 3 min/bed to 5 min/bed to compensate for the reduction in statistics. This should result in a total increase of \~6 min for the whole body scan.

  at the time of scan

Secondary Outcomes (1)

• To determine if whole body PET/CT improves spatial matching of PET and CT

  at the time of scan

Study Arms (1)

Breath-Hold PET/CT image

In addition to the standard clinical PET/CT images, we will provide a breath-hold PET/CT image set, using the same PET data for both.

Other: Breath-Hold PET/CT image set

Interventions

Breath-Hold PET/CT image set OTHER

In addition to the standard clinical PET/CT images, we will provide a breath-hold PET/CT image set, using the same PET data for both. In order to spatially match PET, and therefore improve attenuation correction in the PET images, we will acquire a Breath-Hold CT at 310 mA over the same region covered by PET. The normal-organ doses accumulated from the additional 30 mA CT. The patient's breathing signal during CT and the whole body PET will be recorded using a video camera and in house developed software. We will compare the clinical PET/CT and Breath-Hold PET/CT in regards to lesion detection, lesion volume, and SUV quantification.

Breath-Hold PET/CT image

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients scheduled for whole body FDG PET/CT examination as part of their routine clinical care.

You may qualify if:

• Participant is capable of providing written consent.
• years of age or older.
• Patient with a known or suspected FDG-avid malignancy in the torso

You may not qualify if:

• none

Sponsors & Collaborators

• Memorial Sloan Kettering Cancer Center: lead

Study Sites (1)

Memorial Sloan-Kettering Cancer Center

New York, New York, 10065, United States

Location

Related Links

• Memorial Sloan-Kettering Cancer Center

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Heiko Schoder, MD

  Memorial Sloan Kettering Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 20, 2010
• First Posted: April 23, 2010
• Study Start: April 1, 2010
• Primary Completion: March 1, 2012
• Study Completion: March 1, 2012
• Last Updated: March 16, 2012

Record last verified: 2012-03

Locations

US (1)