Regional Lung Opening and Closing Pressures in Patients With Acute Lung Injury

NCT01107847 | Unknown

• 1 other identifier: UKSH ROP/RCP
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is the measurement of regional opening and closing pressures of lung tissue by electrical impedance tomography in lung healthy and patients with acute lung injury. These values might help the setting of positive endexpiratory pressure during artificial ventilation to avoid the cyclic opening and closing of alveoli.

Conditions

Acute Lung Injury

Keywords

electrical impedance tomography; EIT; acute lung injury; regional lung opening pressure; regional lung closing pressure

Outcome Measures

Primary Outcomes (1)

• Measurement of regional lung opening pressures

  For the measurement of regional opening pressures in lung healthy and acute lung injury an inspiratory low flow manoeuvre with synchronous measurement of regional ventilation and airway pressure is performed. The regional opening pressures are defined as the airway pressure to the point were the regional lung areas open up.

  one year

Secondary Outcomes (1)

• Measurement of regional closing pressures

  one year

Interventions

low flow pressure volume manoeuvre PROCEDURE

In all patients a standard low flow pressure volume manoeuvre is applied by a respirator with a constant gas flow of 4 l/min starting at a zero end-expiratory pressure up to a tidal volume of 2 l or until a maximum airway pressure of 35 cm H2O was reached.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• artificial ventilation
• acute lung injury / healthy lung (control group)

You may not qualify if:

• pregnancy
• Cerebral trauma / surgery
• Age \< 18 years
• instable cardiovascular disease
• instable chest wall

Sponsors & Collaborators

• University Hospital Schleswig-Holstein: lead

Study Sites (1)

Department of Anesthesiology and Intensive Care Medicine, University Medical Center of Schleswig-Holstein, Campus Kiel

Kiel, 24105, Germany

RECRUITING

Related Publications (3)

• Caironi P, Cressoni M, Chiumello D, Ranieri M, Quintel M, Russo SG, Cornejo R, Bugedo G, Carlesso E, Russo R, Caspani L, Gattinoni L. Lung opening and closing during ventilation of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2010 Mar 15;181(6):578-86. doi: 10.1164/rccm.200905-0787OC. Epub 2009 Nov 12.

  PMID: 19910610 BACKGROUND

• Wrigge H, Zinserling J, Muders T, Varelmann D, Gunther U, von der Groeben C, Magnusson A, Hedenstierna G, Putensen C. Electrical impedance tomography compared with thoracic computed tomography during a slow inflation maneuver in experimental models of lung injury. Crit Care Med. 2008 Mar;36(3):903-9. doi: 10.1097/CCM.0B013E3181652EDD.

  PMID: 18431279 BACKGROUND

• Victorino JA, Borges JB, Okamoto VN, Matos GF, Tucci MR, Caramez MP, Tanaka H, Sipmann FS, Santos DC, Barbas CS, Carvalho CR, Amato MB. Imbalances in regional lung ventilation: a validation study on electrical impedance tomography. Am J Respir Crit Care Med. 2004 Apr 1;169(7):791-800. doi: 10.1164/rccm.200301-133OC. Epub 2003 Dec 23.

  PMID: 14693669 BACKGROUND

MeSH Terms

Conditions

Acute Lung Injury

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Jens Scholz, M.D.

  University Medical Center of Schleswig-Holstein, Campus Kiel, Department of Anesthesiology and Intensive Care Medicine

  STUDY CHAIR

Central Study Contacts

Sven Pulletz, M.D.

CONTACT

+49 431 597 2991; pulletz@anaesthesie.uni-kiel.de

Study Design

• Study Type: interventional
• Phase: not applicable
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 19, 2010
• First Posted: April 21, 2010
• Last Updated: April 21, 2010

Record last verified: 2010-03

Locations

DE (1)