NCT01105013

Brief Summary

This is a study clinical, multicenter, Phase III trial, to evaluate the efficacy and safety of tolnaftate cream in the treatment of patients with fungal infections such as Tinea foot, Tinea and Tinea crural body.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
90

participants targeted

Target at below P25 for phase_3

Timeline
Completed

Started Apr 2012

Shorter than P25 for phase_3

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 14, 2010

Completed
2 days until next milestone

First Posted

Study publicly available on registry

April 16, 2010

Completed
2 years until next milestone

Study Start

First participant enrolled

April 1, 2012

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2012

Completed
Last Updated

April 12, 2012

Status Verified

April 1, 2012

Enrollment Period

3 months

First QC Date

April 14, 2010

Last Update Submit

April 11, 2012

Conditions

Keywords

fungal infectionstineatonaftato

Outcome Measures

Primary Outcomes (1)

  • Evaluate the efficacy and safety of the tolnaftate cream 10 mg / g.

    Apply the product in sufficient quantity to cover the affected area 2 times daily (every 12 hours) for 60 days.

    97 days

Study Arms (1)

tonaftato

EXPERIMENTAL

Apply the product in sufficient quantity to cover the affected area 2 times daily (every 12 hours) for 60 days.

Drug: Clotrimazole

Interventions

Apply the product in sufficient quantity to cover the affected area 2 times daily (every 12 hours) for 60 days.

tonaftato

Eligibility Criteria

Age12 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Patients of both sexes, of any race, aged 12 years;
  • Ability to understand and sign the IC (for patients older than age) in the case of minors monitoring and consent of a guardian;
  • Clinical diagnosis of fungal infections for tinea pedis (ringworm of the feet) or tinea cruris (ringworm of the groin region), or tinea corporis (ringworm in other body areas);
  • Direct mycological exam positive for fungi;

You may not qualify if:

  • Pregnant women or nursing mothers;
  • Use of topical or oral antifungal;
  • Use of steroids;
  • Allergy or hypersensitivity to any component of product;
  • Clinical cases of tinea infection by bacteria and / or eczema, tinea extensive and onychomycosis.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculdade de Medicina do ABC

Santo André, São Paulo, Brazil

Location

MeSH Terms

Conditions

MycosesTinea PedisTinea CrurisTinea

Interventions

Clotrimazole

Condition Hierarchy (Ancestors)

Bacterial Infections and MycosesInfectionsDermatomycosesSkin Diseases, InfectiousFoot DermatosesFoot DiseasesSkin DiseasesSkin and Connective Tissue DiseasesPruritusSkin ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsIntertrigoDermatitisSkin Diseases, Eczematous

Intervention Hierarchy (Ancestors)

ImidazolesAzolesHeterocyclic Compounds, 1-RingHeterocyclic Compounds

Study Officials

  • Dagoberto Brandão

    PHC - Pharma Consulting

    STUDY DIRECTOR

Central Study Contacts

Carlos Machado Filho, investigator

CONTACT

Monice Karolis, coordinator

CONTACT

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NON RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 14, 2010

First Posted

April 16, 2010

Study Start

April 1, 2012

Primary Completion

July 1, 2012

Study Completion

July 1, 2012

Last Updated

April 12, 2012

Record last verified: 2012-04

Locations