Cross-Education Of Contralateral Antagonists

NCT01103232 | Completed Results DMC

• 1 other identifier: VGEAH FTR
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

Previous studies well documented the impact of unilateral training of limb muscle on the untrained contralateral homologous muscle. The aim of this study is to evaluate whether the electrical muscle stimulation on the dominant wrist flexors for 6 weeks cause an increase in the muscle strength of the contralateral wrist extensors in healthy adult men. Ethical approval was obtained from Institutional Review Board. All participants were volunteers and provided written informed consent. Among young adult males working in our hospital, 30 subjects who voluntarily accepted to participate in this study were assessed for eligibility. Twenty three young-adult healthy males were included in this double-blind prospective study. These volunteers were randomized into two groups. In Electrical Muscle Stimulation (EMS) group, electrical muscle stimulation of the right wrist flexor muscles was applied; in Controls, transcutaneous electrical nerve stimulation was applied. Electrodes were placed over the flexor aspect of the right forearm in both groups. Electrical stimulation was applied for thirty sessions (one session a day, five days a week for six weeks) in both groups by the same researcher. Compex2 (Medicompex SA, Switzerland) was used for electrical stimulation. Isokinetic torque was measured in the right and left wrist flexors and extensors before and after trial. Isokinetic torque was measured in the right (trained) and left (untrained) forearm with the Cybex (Humac 2004/Norm) extremity-testing system.

Conditions

Muscle Strength Quantitative Trait Locus 1

Keywords

Cross education; Muscle training

Outcome Measures

Primary Outcomes (1)

• Changes in Muscle Strength in the Contralateral Untrained Wrist Muscles

  Isokinetic torque was measured in the contralateral untrained wrist muscles with the Cybex (Humac 2004/Norm) extremity-testing system before and after experiment.

  6 weeks (The change calculated as 6 months minus baseline)

Study Arms (2)

Electrical Muscle Stimulation

EXPERIMENTAL

Electrical muscle stimulation of the right wrist flexor muscles was applied

Procedure: Experimental group

Control

SHAM COMPARATOR

Transcutaneous electrical nerve stimulation was applied

Procedure: Control group

Interventions

Experimental group PROCEDURE

Electrical muscle stimulation (EMS) of the right wrist flexor muscles was applied. EMS was applied for 20 minutes. Maximum current intensity tolerated was used so as to stimulate the highest possible number of motor unit. The stimulation intensity increased every five minutes during a session. Electrical stimulation was applied for thirty sessions (one session a day, five days a week for six weeks.)

Also known as: Electrical Muscle Stimulation

Electrical Muscle Stimulation

Control group PROCEDURE

Conventional mode of transcutaneous electrical nerve stimulation (TENS) was applied for the control subjects. TENS was applied for 20 minutes. The stimulus intensity was adjusted as the lowest current at which the subject felt only a slight tickling of the impulses. A visible, and palpable muscle contraction was not provided during TENS stimulation. The stimulus intensity was not changed during the first session. Subsequently, TENS was applied at same intensity in all sessions. TENS was applied for thirty sessions (one session a day, five days a week for six weeks).

Also known as: Transcutaneous electrical muscle stimulation

Control

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• young-adult healthy volunteer
• male
• right hand dominant

You may not qualify if:

• a chronic disease such as metabolic/endocrine bone disease (osteoporosis, osteomalacia, paget's disease etc)
• myopathy
• tendinopathy
• neurologic disorders (hypoesthesia/anesthesia, epilepsy, paralysis)
• dermatologic disease
• peripheral vascular disease
• joint disease
• cardiac pacemaker
• noncooperative
• professional sportsman
• regular sportive activity such as tennis, volleyball
• heavy worker

Sponsors & Collaborators

• Vakif Gureba Training and Research Hospital: lead

Related Publications (1)

• Sariyildiz M, Karacan I, Rezvani A, Ergin O, Cidem M. Cross-education of muscle strength: cross-training effects are not confined to untrained contralateral homologous muscle. Scand J Med Sci Sports. 2011 Dec;21(6):e359-64. doi: 10.1111/j.1600-0838.2011.01311.x. Epub 2011 Apr 18.

  PMID: 21496110 DERIVED

MeSH Terms

Interventions

Control Groups

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Limitations and Caveats

This study has small sample size.

Results Point of Contact

• Title: ILHAN KARACAN
• Organization: Vakif Gureba Training and Research Hospital

ilhankaracan@hotmail.com

+ 90 212 4531700

Study Officials

• ILHAN KARACAN, MD

  Vakif Gureba Training & Research Hospital

  STUDY CHAIR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief of Physical Med & Rehab Clinic

Study Record Dates

• First Submitted: April 12, 2010
• First Posted: April 14, 2010
• Study Start: January 1, 2008
• Primary Completion: April 1, 2009
• Study Completion: June 1, 2009
• Last Updated: June 25, 2012
• Results First Posted: March 26, 2012

Record last verified: 2012-06