Early Incidence of Occupational Asthma Among Bakers, Pastry-makers and Hairdressers

NCT01096537 | Completed

• 1 other identifier: 2008-A00622-53
• Study Type: observational
• Target: 866
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors. Because most of the data are derived from registries and cross-sectional studies, little is known about incidence of occupational asthma (OA) during the first years after inception of exposure. This study focuses on this early asthma onset period among young workers in the bakery, pastry making and hairdressing sectors in order to assess early incidence of OA in these "at risk" occupations according to exposure duration, and to identify risk factors of OA. Methods: This study is a longitudinal retrospective study with a nested case-control to identify risk factors of OA. The assessment of incidence evolution is made by exploring a series of promotions (or retrospective cohorts) with increasing duration since at work. The study population is composed of subjects who graduated between 2001 and 2006 in sectors where they experience exposure to organic or inorganic allergenic or irritant compounds (with an objective of 150 subjects by year) and 250 young workers with no specific occupational exposure. This study is a descriptive, monocentric, longitudinal and retrospective study with cross-sectional measurements.

Conditions

Occupational Asthma

Keywords

incidence; young workers; occupations at risk; public health; epidemiology; polymorphisms; gentic

Outcome Measures

Primary Outcomes (1)

• The early incidence of OA among young workers according to their sector of activity and exposure duration.

  3-6 months after tle last inclusion

Secondary Outcomes (1)

• The identification of risk factors of OA.

  3-6 months after the last inclusion

Study Arms (1)

Young workers

Exposed young workers graduated in sectors at risk of occupational asthma (bakery, pastry-making or hairdressing) "Non-exposed" young workers graduated in sectors without specific occupational exposure as the sale or the food sectors.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All bakers, pastry-makers and hairdressers who graduated between 2001 and 2006 from nine vocational schools in Lorraine, North-Eastern France, and all subjects who graduated in 2001 in the sale or the food sectors (butcher, pork butcher, caterer, cook job,…) from the same vocational schools.

You may qualify if:

• for the exposed group: to be graduated between 2001 and 2006 from nine vocational schools in Lorraine, North-Eastern France
• for the "non-exposed" group: to be graduated in 2001 in the sale or the food sectors (butcher, pork butcher, caterer, cook job,…) from the same vocational schools

You may not qualify if:

• asthma diagnosed before apprenticeship
• for the "non-exposed" group: to have worked previously or later in a sector at risk with OA

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator
• University of Nancy: collaborator

Study Sites (1)

CHU Nancy

Nancy, 54000, France

Location

Related Publications (1)

• Remen T, Coevoet V, Acouetey DS, Gueant JL, Gueant-Rodriguez RM, Paris C, Zmirou-Navier D. Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study. BMC Public Health. 2010 Apr 26;10:206. doi: 10.1186/1471-2458-10-206.

  PMID: 20420675 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

whole blood, serum, plasma

MeSH Terms

Conditions

Asthma, Occupational

Condition Hierarchy (Ancestors)

Asthma; Bronchial Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Occupational Diseases

Study Officials

• Christophe PARIS, MD / PhD

  CHU Nancy, INSERM, Nancy University

  PRINCIPAL INVESTIGATOR

• Denis ZMIROU-NAVIER, MD / PhD

  INSERM, Nancy university, EHESP School of Public Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 10, 2010
• First Posted: March 31, 2010
• Study Start: December 1, 2008
• Primary Completion: January 1, 2010
• Study Completion: June 1, 2010
• Last Updated: July 6, 2016

Record last verified: 2016-03

Locations

FR (1)