The Neuroeconomics of Behavioral Therapies for Adolescent Substance Abuse

NCT01093898 | Completed

• 2 other identifiers: 368241R21DA029442-01
• Study Type: observational
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

This study will measure the brain activity of adolescent substance abusers while they make decisions about their preferences to receive smaller, immediate rewards versus larger delayed rewards. The investigators expect that patterns of brain activity while engaged in this decision making task will predict response to treatment among adolescent substance users. The investigators expect to use the results of this study to develop more effective treatments for adolescent substance abuse

Conditions

Adolescent Substance Use

Outcome Measures

Primary Outcomes (1)

• delay discounting

  laboratory task assessing preference for immediate rewards

  Assessed at baseline

Study Arms (1)

No intervention

Eligibility Criteria

• Age: 12 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Adolescents recruited into the Marijuana Trial and the Alcohol Trial during the period of the R21 project would participate in a single neuroimaging session as soon after the intake session as possible.

You may qualify if:

• Participants must be 12 to 18 years old and have a parent/guardian who can participate.
• Report using marijuana during the previous 30 days or provide a marijuana-positive urine test, plus meet criteria for Cannabis Abuse or Dependence OR
• Meet Diagnostic Statistical Manual (DSM) criteria for Alcohol Abuse or dependence or have had one binge episode, specified by ≥5 drinks in one day, in the past 90 days and report alcohol use in the past 30 days.

You may not qualify if:

• Contraindications to MRI including ferromagnetic implants or claustrophobia
• Meeting DSM criteria for dependence on illicit drugs other than marijuana or alcohol (use/abuse of other drugs will not be excluded)
• Exhibit active psychosis, have severe medical or psychiatric illness limiting participation
• Are pregnant or breast-feeding.

Sponsors & Collaborators

• Dartmouth-Hitchcock Medical Center: lead
• National Institutes of Health (NIH): collaborator
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

Geisel School of Medicine at Dartmouth

Lebanon, New Hampshire, 03756, United States

Location

Related Publications (1)

• Stanger C, Elton A, Ryan SR, James GA, Budney AJ, Kilts CD. Neuroeconomics and adolescent substance abuse: individual differences in neural networks and delay discounting. J Am Acad Child Adolesc Psychiatry. 2013 Jul;52(7):747-755.e6. doi: 10.1016/j.jaac.2013.04.013. Epub 2013 Jun 5.

  PMID: 23800488 RESULT

Study Officials

• Catherine Stanger, Ph.D.

  Dartmouth College

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 23, 2010
• First Posted: March 26, 2010
• Study Start: April 1, 2010
• Primary Completion: May 1, 2014
• Study Completion: May 1, 2014
• Last Updated: March 19, 2018

Record last verified: 2018-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)