NCT01089985

CompletedPhase 1

Use of Autologous Serum Eye-drops as Tears in Patients With ...

Singapore National Eye Centre Source

Compare

Other study identifiers

Sponsor study identifier

R724/08/2010

Study Type

interventional

Actual enrollment (reported)

10

Locations

1 country

Sites

1

Timeline

Study Start

July 2010

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

December 2011

Actual (reported)

Study Completion

December 2011

Actual (reported)

Brief Summary

The purpose of this study is to examine the efficacy and safety of autologous serum eye drops in people with recalcitrant dry eye.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 10 participants
Study completion date: December 2011
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
March 16, 2010
Actual (reported)
First Posted
March 19, 2010
Actual (reported)
Study Start
July 2010
Date type not reported
This date has not been verified as actual or estimated.
Primary Completion
December 2011
Actual (reported)
Study Completion
December 2011
Actual (reported)

Last Updated: January 18, 2012
Status Verified: January 2012
Last Update Submitted: January 15, 2012

Conditions

Xerophthalmia

Outcome Measures

Primary Outcomes (1)

Staining
Grading of punctate corneal staining in the worse eye (second visit relative to first visit)
4 months

Secondary Outcomes (6)

Symptoms
4 months
Tear-production
4 months
Tear-proteins
4 months
Tear-stability
4 months
Cornea
4 months
+1 more secondary outcomes

Study Arms (1)

Serum eye drops

EXPERIMENTAL

Patient's autologous serum is diluted in saline solution

Drug: Autologous serum eyedrops

Interventions

Autologous serum eyedropsDrug

3 times a day for the duration of the study

Serum eye drops

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age21 Years - 75 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Seen at the dry eye service at the Singapore National Eye Centre
Age between 21 and 75 years old

Sponsors & Collaborators

Singapore National Eye Centre
Governmentlead

Study Sites (1)

Singapore National Eye Centre

Singapore, Singapore, 168571, Singapore

MeSH Terms

Conditions

Xerophthalmia

Condition Hierarchy (Ancestors)

Conjunctival DiseasesEye DiseasesDry Eye SyndromesLacrimal Apparatus Diseases

Study Officials

Louis Tong, FRCS, MD
Singapore National Eye Centre
PRINCIPAL INVESTIGATOR
Ronald Chung
Singapore National Eye Centre
PRINCIPAL INVESTIGATOR
Roger Beuerman
Singapore Eye Research Institute
STUDY DIRECTOR
Mickey Koh
Singapore General Hospital
STUDY CHAIR

Enrollment

10 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: phase 1
Allocation: NA
Masking: NONE
Purpose: TREATMENT
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER GOV
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Clinician-Scientist

Study Record Dates

First Submitted

March 16, 2010

First Posted

March 19, 2010

Study Start

July 2010

Date type not reported

This date has not been verified as actual or estimated.

NCT04877483

To Evaluate the Short-term and Long Term Efficacy of Acupuncture in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome

Not ApplicableUnknown

NCT05656196

VGH-DESJS-1 in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome and Sjögren's Syndrome

Not ApplicableCompleted

NCT06475027

Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome

Not Yet Recruiting

NCT07551843

Comparative Effects of Autologous Serum, Umbilical Cord Blood-Derived Drops, and Platelet Lysate on Ocular Surface Parameters

Phase 1/2Completed

NCT06771427

Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome

Recruiting

Symptomatic for dry eye or VA worse than 6/12 in Snellen chart

Presence of corneal punctate staining involving central zone

Exhausted what is considered as standard therapy or therapy that is acceptable to the patient and the physician

No contraindication for blood extraction/plasmapheresis

You may not qualify if:

HIV/HCV/HBV/syphilis

Contact the study team to confirm eligibility.

Samanthila Waduthantri

Singapore National Eye Centre

STUDY CHAIR

Heng Joo Ng

Singapore General Hospital

STUDY CHAIR

Rohani Salleh

Singapore General Hospital

STUDY CHAIR

Primary Completion

December 2011

Actual (reported)

Study Completion

December 2011

Actual (reported)

Last Updated

January 18, 2012

Record last verified: 2012-01

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT01089985
Data provider: ClinicalTrials.gov
Source updated: 2012-01-18
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:20:57 UTC

Locations

SG(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (6)

Study Arms (1)

Serum eye drops

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations