Sponsor study identifier
observational
133
1 country
3
Study Start
November 2007
Actual (reported)Primary Completion
November 2012
Actual (reported)Study Completion
June 2021
Actual (reported)Which are the anthropometric parameters and/or of severity of the syndrome of apnea of sleep (SAS) which make it possible to anticipate occurred of vascular anomalies, anatomical and/or functional precociously found among patients SAS? Secondary objectives:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2021
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 2007
Actual (reported)March 16, 2010
Actual (reported)March 18, 2010
Actual (reported)November 2012
Actual (reported)June 2021
Actual (reported)Patients with obstructive sleep apnea syndrome (Apnea/Hypopnea index \> 15)
France : Laboratoire d'explorations fonctionnelles du système nerveux - Functional explorations laboratory of nervous system
Clermont-Ferrand, 63000, France
France : Laboratoire EFCR - Functional cardiorespiratory explorations laboratory
Grenoble, 38000, France
France : Laboratoire EFCR - Functional cardiorespiratory explorations laboratory
Saint-Etienne, 42000, France
Lattimore JD, Celermajer DS, Wilcox I. Obstructive sleep apnea and cardiovascular disease. J Am Coll Cardiol. 2003 May 7;41(9):1429-37. doi: 10.1016/s0735-1097(03)00184-0.
Parish JM, Somers VK. Obstructive sleep apnea and cardiovascular disease. Mayo Clin Proc. 2004 Aug;79(8):1036-46. doi: 10.4065/79.8.1036.
Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA. 2003 Oct 8;290(14):1906-14. doi: 10.1001/jama.290.14.1906.
Jean-Louis JP PEPIN, ProfessorPhD
University Hospital, Grenoble
133 participants (actual enrollment reported by the registry).
First Submitted
March 16, 2010
First Posted
March 18, 2010
Study Start
November 2007
Actual (reported)Preventive Effects of Bosentan on the Systemic Cardiovascular Consequence of Sleep Apnea
Contact the study team to confirm eligibility.
Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005 Mar 19-25;365(9464):1046-53. doi: 10.1016/S0140-6736(05)71141-7.
Drager LF, Bortolotto LA, Lorenzi MC, Figueiredo AC, Krieger EM, Lorenzi-Filho G. Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med. 2005 Sep 1;172(5):613-8. doi: 10.1164/rccm.200503-340OC. Epub 2005 May 18.
Baguet JP, Boutin I, Barone-Rochette G, Levy P, Tamisier R, Pierre H, Boggetto-Graham L, Pepin JL. Hypertension diagnosis in obstructive sleep apnea: self or 24-hour ambulatory blood pressure monitoring? Int J Cardiol. 2013 Sep 1;167(5):2346-7. doi: 10.1016/j.ijcard.2012.11.037. Epub 2012 Nov 22. No abstract available.
Stanke-Labesque F, Pepin JL, de Jouvencel T, Arnaud C, Baguet JP, Petri MH, Tamisier R, Jourdil JF, Levy P, Back M. Leukotriene B4 pathway activation and atherosclerosis in obstructive sleep apnea. J Lipid Res. 2012 Sep;53(9):1944-51. doi: 10.1194/jlr.P022814. Epub 2012 Jul 3.
Primary Completion
November 2012
Actual (reported)Study Completion
June 2021
Actual (reported)Last Updated
December 29, 2025
Record last verified: 2025-12
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Source: ClinicalTrials.gov.
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