Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)

NCT01088217 | Unknown

• 1 other identifier: 2R01HL097163
• Study Type: observational
• Target: 8,000
• Locations: 2 countries
• Sites: 4

Brief Summary

The purpose of this study is to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis and to identify a group of genes that predispose individuals to develop pulmonary fibrosis. Finding the genes that cause pulmonary fibrosis is the first step at developing better methods for early diagnosis and improved treatment for pulmonary fibrosis. The overall hypothesis is that inherited genetic factors predispose individuals to develop pulmonary fibrosis.

Conditions

Idiopathic Pulmonary Fibrosis; Familial Pulmonary Fibrosis; Idiopathic Interstitial Pneumonia; Familial Interstitial Pneumonia

Keywords

Idiopathic Pulmonary Fibrosis; Familial Pulmonary Fibrosis; Idiopathic Interstitial Pneumonia; Familial Interstitial Pneumonia; Pulmonary Fibrosis

Outcome Measures

Primary Outcomes (1)

• Identify a group of genetic loci that play a role in the development of familial interstitial pneumonia and idiopathic interstitial pneumonia.

  The purpose of this study is to investigate inherited genetic factors that play a role in the development of pulmonary fibrosis and to identify a group of genetic loci/genes that predispose individuals to develop IIP. We will achieve this goal by employing various methods of genetic technology for gene discovery.

  10 years

Secondary Outcomes (1)

• Develop biomarkers using proteomic and genomic approaches that will facilitate establishing the diagnosis and prognosis of both familial and sporadic forms of idiopathic interstitial pneumonia (IIP).

  10 years

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Families with two or more individuals diagnosed with Idiopathic Pulmonary Fibrosis (IPF) or Idiopathic Interstitial Pneumonia (IIP)

You may qualify if:

• Two or more family members with a clinical diagnosis of Idiopathic Pulmonary Fibrosis (IPF) or Idiopathic Interstitial Pneumonia (IIP)
• Additional family members may be eligible to participate if two family members are suspected of or diagnosed as having Idiopathic Pulmonary Fibrosis (IPF) or Idiopathic Interstitial Pneumonia (IIP)

You may not qualify if:

• Individuals whose pulmonary fibrosis is due to a known cause rather than idiopathic
• Individuals whose pulmonary fibrosis is due to a broader genetic syndrome

Sponsors & Collaborators

• National Jewish Health: lead
• University of Colorado, Denver: collaborator
• Vanderbilt University: collaborator
• Landspitali University Hospital: collaborator

Study Sites (4)

University of Colorado Denver

Aurora, Colorado, 80045, United States

RECRUITING

National Jewish Health and University of Colorado Denver

Denver, Colorado, 80206, United States

RECRUITING

Vanderbilt University

Nashville, Tennessee, 37232, United States

RECRUITING

Landspitali University Hospital

Reykjavik, Iceland

RECRUITING

Related Links

• Click here to learn more about Familial Pulmonary Fibrosis and this study.

Biospecimen

Retention: SAMPLES WITH DNA

whole blood, serum, plasma, lung tissue, DNA, RNA

MeSH Terms

Conditions

Idiopathic Pulmonary Fibrosis; Idiopathic Interstitial Pneumonias; Pulmonary Fibrosis

Condition Hierarchy (Ancestors)

Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• David A. Schwartz, MD

  University of Colorado Denver; National Jewish Health

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Julie Powers, MHS

CONTACT

303-724-6539; julia.powers@ucdenver.edu

Janet Talbert, MS, CGC

CONTACT

1-800-423-8891; talbertj@njhealth.org

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 15, 2010
• First Posted: March 17, 2010
• Study Start: July 1, 2008
• Primary Completion: June 1, 2025
• Study Completion: June 1, 2025
• Last Updated: September 14, 2020

Record last verified: 2020-09

Locations

US (3); IC (1)