Connect™ CLL: The Chronic Lymphocytic Leukemia Disease Registry
1 other identifier
observational
1,494
1 country
165
Brief Summary
The purpose of the Connect™ Chronic Lymphocytic Leukemia (CLL) Disease Registry is to explore the history and real world management of patients diagnosed with CLL, provide insight into the management of CLL, and evaluate the effectiveness of first, second and subsequent therapeutic strategies employed in both the community and academic settings.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2010
Longer than P75 for all trials
165 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 4, 2010
CompletedFirst Posted
Study publicly available on registry
March 5, 2010
CompletedStudy Start
First participant enrolled
March 19, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2017
CompletedMay 12, 2020
May 1, 2020
7.8 years
March 4, 2010
May 8, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Identify and summarize patterns in therapeutic regimens and patient outcomes
The primary objective is to 1) describe practice patterns of first line therapy regimens and subsequent therapeutic strategies in patients initiated on therapy for CLL, as well as initiated on second line and subsequent therapies, in the community and academic setting (2) Provide insight into therapeutic regimens and therapy sequence in clinical practice as they relate to clinical outcomes in patients initiated on first-line, second-line or subsequent therapies for CLL.
up to 8 years
Secondary Outcomes (2)
Summarize Effectiveness of Treatment Regimens
up to 8 years
Health Related Quality of Life Measures Related to Therapeutic Regimens
up to 8 years
Eligibility Criteria
An adult population (\>=18 years old) of both men and women who have chronic lymphocytic leukemia treated in either community or academic medical centers.
You may qualify if:
- Clinical diagnosis with CLL
- Clinical decision made to initiate first-line therapy, second-line therapy or subsequent line of therapy prior to enrollment into the ConnectTM CLL registry, but within 2 months of enrollment
- Age≥18 years
- Willing and able to provide signed informed consent
- Willing and able to complete patient assessment questionnaires either alone or with minimal assistance from caregivers and/or trained site personnel
You may not qualify if:
- Participation in a clinical study in which study treatment is blinded
- Patient condition is considered terminal (i.e.\<6 months to live)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Celgenelead
Study Sites (165)
New Hope Cancer & Research Institute
Pomona, California, 91767, United States
Medical Specialists of the Palm Beaches
Atlantis, Florida, 33462, United States
University Cancer Institute
Boynton Beach, Florida, 33426, United States
Thomas Niederman, MD
Boynton Beach, Florida, 33435, United States
Pasco Hernando Oncology Associates (Kumar)
New Port Richey, Florida, 34652, United States
Phoebe Putney Memorial Hospital
Albany, Georgia, 31701, United States
Peachtree Hematology-Oncology Consultants
Atlanta, Georgia, 30318, United States
Georgia Cancer Specialists
Atlanta, Georgia, 30331, United States
US Oncology - Dublin Hematology & Oncology
Dublin, Georgia, 31021, United States
Straub Clinic and Hospital
Honolulu, Hawaii, 96816, United States
US Oncology - Cancer Care & Hematology Specialists of Chicagoland - Arlington
Arlington Heights, Illinois, 60005, United States
John H. Stroger, Jr., Hospital of Cook County
Chicago, Illinois, 60612, United States
Rush University Medical Center
Chicago, Illinois, 60612, United States
Ingalls Cancer Research Center
Harvey, Illinois, 60426, United States
Elmhurst Memorial Hospital
Lombard, Illinois, 60148, United States
Oncology Specialists, S.C.
Niles, Illinois, 60714, United States
US Oncology - Cancer Care & Hematology Specialists of Chicagoland - Niles
Niles, Illinois, 60714, United States
Illinois Cancer Care
Peoria, Illinois, 61615, United States
Orchard Research
Skokie, Illinois, 60076, United States
Carle Cancer Center
Urbana, Illinois, 61801, United States
US Oncology - Cancer Care & Hematology Specialists of Chicagoland - Winfield
Winfield, Illinois, 60190, United States
St. Francis Cancer Research
Beech Grove, Indiana, 46107, United States
Center for Cancer Care @ Goshen Health Systems
Goshen, Indiana, 46526, United States
Indiana University Cancer Center Clinical Research Office
Indianapolis, Indiana, 46202, United States
Cancer Care Partners, LLC
Mishawaka, Indiana, 46545, United States
Cancer Care Center, Inc.
New Albany, Indiana, 47150, United States
McFarland Clinic
Ames, Iowa, 50010, United States
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, 52722, United States
Iowa Blood and Cancer Care of PCI
Cedar Rapids, Iowa, 52402, United States
Covenant Clinic
Waterloo, Iowa, 50702, United States
Cancer Center of Kansas, PA
Wichita, Kansas, 67214, United States
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, 70809, United States
Western Maryland Health System, Inc.
Cumberland, Maryland, 21502, United States
Alliance Hematology Oncology, PA
Westminster, Maryland, 21157, United States
Capecod Hospital / Davenport Mugar Cancer Center
Hyannis, Massachusetts, 02601, United States
Fallon Clinic
Worcester, Massachusetts, 01608, United States
Michigan State University / McLaren Regional Medical Center
Flint, Michigan, 48532, United States
Cancer and Hematology Centers of Western Michigan
Grand Rapids, Michigan, 49503, United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007, United States
Duluth Clinic Cancer Center
Duluth, Minnesota, 55805, United States
Park Nicollet Institute Metro - MN CCOP
Saint Louis Park, Minnesota, 55416, United States
Park Nicollet Institute - Louisiana Ave.
Saint Louis Park, Minnesota, 55426, United States
US Oncology - University of Tennessee Cancer Institute - Southaven
Southaven, Mississippi, 38671, United States
US Oncology - Missouri Cancer Associates
Columbia, Missouri, 65201, United States
Capitol Comprehensive Cancer Care Clinic
Jefferson City, Missouri, 65109, United States
St. Joseph Oncology, Inc.
Saint Joseph, Missouri, 64507, United States
St. John's Medical Research Institute
Springfield, Missouri, 65807, United States
Hematology Oncology Consultants, Inc.
St Louis, Missouri, 63136, United States
Montana Cancer Institute Foundation
Missoula, Montana, 59802, United States
Nebraska Hematology Oncology, PC
Lincoln, Nebraska, 68506, United States
Southeast Nebraska Hematology & Oncology Consultants, PC
Lincoln, Nebraska, 68510, United States
Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106, United States
VA Sierra Nevada Healthcare System
Reno, Nevada, 89502, United States
The Center for Cancer and Hematologic Disease
Cherry Hill, New Jersey, 08003, United States
Drs. Forte, Schleider, Attas & Condemi, PA
Englewood, New Jersey, 07432, United States
Charles Farber, MD
Morristown, New Jersey, 07962, United States
Hematology Oncology of Northern New Jersey
Morristown, New Jersey, 07962, United States
Steeplechase Cancer Center
Somerville, New Jersey, 08876, United States
Samuel S Stratton VAMC
Albany, New York, 12208, United States
Hematology Oncology Associates of Western Suffolk
Bay Shore, New York, 11706, United States
Eduardo Saponara, MD
Bronxville, New York, 10708, United States
Jonah Cancer Care Center & ECMC
Buffalo, New York, 14215, United States
Broome Oncology
Johnson City, New York, 13790, United States
SUNY Upstate Medical University - Adult Program
Syracuse, New York, 14222, United States
Bronx River Medical Associates
The Bronx, New York, 10467, United States
Eastchester Center for Cancer Care
The Bronx, New York, 10469, United States
US Oncology - Cancer Centers of North Carolina - Cary
Cary, North Carolina, 27518, United States
US Oncology - Cancer Centers of North Carolina - Macon
Raleigh, North Carolina, 27607, United States
US Oncology - Cancer Centers of North Carolina - Falls
Raleigh, North Carolina, 27614, United States
Legacy Pharma Research
Bismarck, North Dakota, 58501, United States
Roger Maris Cancer Center
Fargo, North Dakota, 58122, United States
Summa Health System - Cancer Research Office
Akron, Ohio, 44304, United States
Gabrail Cancer Center Research
Canton, Ohio, 44718, United States
Mid Ohio Oncology / Hematology, Inc.
Columbus, Ohio, 43219, United States
Hematology Oncology Center, Inc.
Elyria, Ohio, 44035, United States
US Oncology - Willamette Valley Cancer Institute - Eugene
Eugene, Oregon, 97401-8122, United States
US Oncology - Northwest Cancer Specialists, PC - Portland - Hoyt
Portland, Oregon, 97213-2996, United States
US Oncology - Northwest Cancer Specialists, PC - Portland - Barnes
Portland, Oregon, 97225, United States
US Oncology - Northwest Cancer Specialists, PC - Portland - Broadway
Portland, Oregon, 97227, United States
US Oncology - Willamette Valley Cancer Institute - Springfield
Springfield, Oregon, 97477, United States
US Oncology - Northwest Cancer Specialists, PC - Tualatin
Tualatin, Oregon, 97062, United States
Oncology Hematology of Lehigh Valley
Bethlehem, Pennsylvania, 18015, United States
Consultants in Medical Oncology and Hematology, PC
Drexel Hill, Pennsylvania, 19026, United States
Gettysburg Cancer Center
Gettysburg, Pennsylvania, 17325, United States
Andrews and Patel Associates
Harrisburg, Pennsylvania, 17111, United States
US Oncology - Medical Oncology Associates (Nahar)
Kingston, Pennsylvania, 18704, United States
Lancaster Cancer Center
Lancaster, Pennsylvania, 17605, United States
Berks Hematology Oncology Associates
Reading, Pennsylvania, 19612, United States
Hematology & Oncology Associates of Rhode Island
Cranston, Rhode Island, 02920, United States
Charleston Hematology Oncology Associates, PA
Charleston, South Carolina, 29403, United States
South Carolina Oncololgy Associates, PA
Columbia, South Carolina, 29210, United States
US Oncology - Cancer Centers of the Carolinas - Easley
Easley, South Carolina, 29640, United States
US Oncology - Cancer Centers of the Carolinas - Butternut
Greenville, South Carolina, 29605, United States
US Oncology - Cancer Centers of the Carolinas - West Faris
Greenville, South Carolina, 29605, United States
US Oncology - Cancer Centers of the Carlinas - Eastside
Greenville, South Carolina, 29615, United States
US Oncology - Cancer Centers of the Carolinas - Seneca
Seneca, South Carolina, 29672, United States
US Oncology - Cancer Centers of the Carolinas - Spartanburg
Spartanburg, South Carolina, 29307, United States
Sanford Clinic
Sioux Falls, South Dakota, 57104, United States
US Oncology - University of Tennessee Cancer Institute - Bartlett
Bartlett, Tennessee, 38133, United States
Family Cancer Center, PLLC
Collierville, Tennessee, 38017, United States
US Oncology - University of Tennessee Cancer Institute - Germantown
Germantown, Tennessee, 38138, United States
US Oncology - University of Tennessee Cancer Institute - Memphis
Memphis, Tennessee, 38104, United States
SCRI
Nashville, Tennessee, 37203, United States
US Oncology - Texas Cancer Center - Abilene (South)
Abilene, Texas, 79606, United States
US Oncology - Texas Oncology, PA - Amarillo
Amarillo, Texas, 79106, United States
US Oncology - Texas Oncology - Arlington South
Arlington, Texas, 76014, United States
US Oncology - Texas Oncology, PA - Bedford
Bedford, Texas, 76022, United States
St. Joseph Regional Cancer Center
Bryan, Texas, 77802, United States
Scott & White Clinic
College Station, Texas, 77802, United States
South Texas Institute of Cancer
Corpus Christi, Texas, 78405, United States
Coastal Bend Cancer Center
Corpus Christi, Texas, 78463, United States
US Oncology - Texas Oncology, PA - Dallas
Dallas, Texas, 75231, United States
US Oncology - El Paso Cancer Treatment Center - West
El Paso, Texas, 79902, United States
US Oncology - El Paso Cancer Treatment Center
El Paso, Texas, 79902, United States
US Oncology - Texas Oncology, PA - Fort Worth
Fort Worth, Texas, 76104, United States
US Oncology - Southwest Fort Worth Cancer Center
Fort Worth, Texas, 76132, United States
US Oncology - Texas Oncology - Grapevine
Grapevine, Texas, 76051, United States
Oncology Consultants
Houston, Texas, 77024, United States
MD Anderson Cancer Center
Houston, Texas, 77030, United States
US Oncology - San Antonio Tumor & Blood Clinic - Kerrville
Kerrville, Texas, 78028, United States
Wilford Hall Medical Center
Lackland Air Force Base, Texas, 78236, United States
US Oncology - Longview Cancer Center
Longview, Texas, 75601, United States
Joe Arrington Cancer Research and Treatment Center
Lubbock, Texas, 79410, United States
US Oncology - Texas Oncology - McAllen
McAllen, Texas, 78503, United States
US Oncology - Texas Oncology - Mesquite
Mesquite, Texas, 75150, United States
US Oncology - Allison Cancer Center
Midland, Texas, 79701, United States
US Oncology - Texas Oncology - Paris
Paris, Texas, 75460-5004, United States
US Oncology - Cancer Care Centers of South Texas
San Antonio, Texas, 78217, United States
US Oncology - San Antonio Tumor & Blood Clinic - M. Oak
San Antonio, Texas, 78258-3912, United States
US Oncology - Texas Oncology - Sherman
Sherman, Texas, 75090-0504, United States
Scott & White Healthcare Department of Research
Temple, Texas, 76508, United States
ETMC dba Blood and Cancer Center - East Texas
Tyler, Texas, 75701, United States
ETMC dba Tyler Hematology Oncology
Tyler, Texas, 75701, United States
US Oncology - Texas Oncology - Tyler
Tyler, Texas, 75702, United States
US Oncology - Texas Oncology Cancer Care and Research Center
Waco, Texas, 76712, United States
US Oncology - Texas Oncology - Weslaco
Weslaco, Texas, 78596, United States
US Oncology - Texoma Cancer Center
Wichita Falls, Texas, 76310, United States
Central Utah Clinic
American Fork, Utah, 84003, United States
Northern Utah Associates
Ogden, Utah, 84403, United States
US Oncology - Arlington Fairfax Hematology Oncology
Arlington, Virginia, 22205, United States
US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Christiansburg
Christiansburg, Virginia, 24073, United States
US Oncology - Fairfax Northern VA Hem-Onc PC
Fairfax, Virginia, 22031, United States
US Oncology - Fairfax - Northern Virginia Hematology-Oncology, PC - Gainesville
Gainesville, Virginia, 20155, United States
US Oncology - Fairfax - Northern Virginia Hem-Onc, PC - Leesburg
Leesburg, Virginia, 20176, United States
US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Low Moor
Low Moor, Virginia, 24457, United States
US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Roanoke
Roanoke, Virginia, 24014, United States
US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Salem
Salem, Virginia, 24153, United States
US Oncology - Shenandoah Oncology - Winchester
Winchester, Virginia, 22601, United States
US Oncology - Fairfax - Northern Virginia Hem-Onc, PC - Woodbridge
Woodbridge, Virginia, 22191, United States
US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Wytheville
Wytheville, Virginia, 24382, United States
Peace Health Medical Group
Bellingham, Washington, 98226, United States
US Oncology - Puget Sound Cancer Center - Edmonds
Edmonds, Washington, 98133, United States
Providence Everett Medical Center
Everett, Washington, 98201, United States
Columbia Basin Hematology and Oncology
Kennewick, Washington, 99337, United States
US Oncology - Puget Sound Cancer Center - Seattle
Seattle, Washington, 98133, United States
US Oncology - Cancer Care Northwest - Sherman
Spokane, Washington, 99202, United States
Medical Oncology Associates PS
Spokane, Washington, 99208, United States
US Oncology - Cancer Care Northwest - Holland
Spokane, Washington, 99218, United States
US Oncology - Cancer Care Northwest - Mission
Spokane, Washington, 99218, United States
US Oncology - Northwest Cancer Specialists, PC - Vancouver - 136th St.
Vancouver, Washington, 98684, United States
US Oncology - Northwest Cancer Specialists, PC - Vancouver - 134th St
Vancouver, Washington, 98686, United States
Providence St. Mary Regional Cancer Center
Walla Walla, Washington, 99362, United States
US Oncology - Yakima Valley Memorial Hospital/North Star Lodge (Boyd)
Yakima, Washington, 98902, United States
St. Vincent Hospital/Green Bay Oncology
Green Bay, Wisconsin, 54301, United States
Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188, United States
Related Publications (7)
Pashos CL, Flowers CR, Kay NE, Weiss M, Lamanna N, Farber C, Lerner S, Sharman J, Grinblatt D, Flinn IW, Kozloff M, Swern AS, Street TK, Sullivan KA, Harding G, Khan ZM. Association of health-related quality of life with gender in patients with B-cell chronic lymphocytic leukemia. Support Care Cancer. 2013 Oct;21(10):2853-60. doi: 10.1007/s00520-013-1854-z. Epub 2013 Jun 8.
PMID: 23748484RESULTMato A, Nabhan C, Kay NE, Weiss MA, Lamanna N, Kipps TJ, Grinblatt DL, Flinn IW, Kozloff MF, Flowers CR, Farber CM, Kiselev P, Swern AS, Sullivan K, Flick ED, Sharman JP. Real-world clinical experience in the Connect(R) chronic lymphocytic leukaemia registry: a prospective cohort study of 1494 patients across 199 US centres. Br J Haematol. 2016 Dec;175(5):892-903. doi: 10.1111/bjh.14332. Epub 2016 Nov 8.
PMID: 27861736RESULTNabhan C, Mato A, Flowers CR, Grinblatt DL, Lamanna N, Weiss MA, Davids MS, Swern AS, Bhushan S, Sullivan K, Flick ED, Kiselev P, Sharman JP. Characterizing and prognosticating chronic lymphocytic leukemia in the elderly: prospective evaluation on 455 patients treated in the United States. BMC Cancer. 2017 Mar 16;17(1):198. doi: 10.1186/s12885-017-3176-x.
PMID: 28302090RESULTMato A, Nabhan C, Kay NE, Lamanna N, Kipps TJ, Grinblatt DL, Flowers CR, Farber CM, Davids MS, Kiselev P, Swern AS, Bhushan S, Sullivan K, Flick ED, Sharman JP. Prognostic Testing Patterns and Outcomes of Chronic Lymphocytic Leukemia Patients Stratified by Fluorescence In Situ Hybridization/Cytogenetics: A Real-world Clinical Experience in the Connect CLL Registry. Clin Lymphoma Myeloma Leuk. 2018 Feb;18(2):114-124.e2. doi: 10.1016/j.clml.2017.11.010. Epub 2017 Dec 6.
PMID: 29352719RESULTAhn IE, Farber CM, Davids MS, Grinblatt DL, Kay NE, Lamanna N, Mato A, Nabhan C, Kiselev P, Swern AS, Flick ED, Sullivan K, Sharman JP, Flowers CR. Early progression of disease as a predictor of survival in chronic lymphocytic leukemia. Blood Adv. 2017 Nov 28;1(25):2433-2443. doi: 10.1182/bloodadvances.2017011262. eCollection 2017 Nov 28.
PMID: 29296893RESULTFlowers CR, Nabhan C, Kay NE, Mato A, Lamanna N, Farber CM, Davids MS, Kiselev P, Swern AS, Sullivan K, Flick ED, Sharman JP. Reasons for initiation of treatment and predictors of response for patients with Rai stage 0/1 chronic lymphocytic leukemia (CLL) receiving first-line therapy: an analysis of the Connect(R) CLL cohort study. Leuk Lymphoma. 2018 Oct;59(10):2327-2335. doi: 10.1080/10428194.2018.1427860. Epub 2018 Feb 7.
PMID: 29415595RESULTMato A, Nabhan C, Lamanna N, Kay NE, Grinblatt DL, Flowers CR, Farber CM, Davids MS, Swern AS, Sullivan K, Flick ED, Gressett Ussery SM, Gharibo M, Kiselev P, Sharman JP. The Connect CLL Registry: final analysis of 1494 patients with chronic lymphocytic leukemia across 199 US sites. Blood Adv. 2020 Apr 14;4(7):1407-1418. doi: 10.1182/bloodadvances.2019001145.
PMID: 32271900DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Kenneth Foon, MD
Celgene Corporation
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 4, 2010
First Posted
March 5, 2010
Study Start
March 19, 2010
Primary Completion
December 31, 2017
Study Completion
December 31, 2017
Last Updated
May 12, 2020
Record last verified: 2020-05