Effectiveness and Safety of Adalimumab in Rheumatoid Arthritis Patients in Routine Clinical Practice
1 other identifier
observational
5,745
1 country
370
Brief Summary
Observation of safety, tolerability and effectiveness of adalimumab (Humira) therapy in a large patient collective under everyday clinical conditions over a 5-year period.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2003
Longer than P75 for all trials
370 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2003
CompletedFirst Submitted
Initial submission to the registry
February 26, 2010
CompletedFirst Posted
Study publicly available on registry
March 2, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2013
CompletedResults Posted
Study results publicly available
April 23, 2014
CompletedMay 8, 2014
April 1, 2014
9.9 years
February 26, 2010
March 19, 2014
April 23, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change From Baseline in Disease Activity Score (DAS) 28
The DAS28 is a validated index of rheumatoid arthritis disease activity. Twenty-eight tender joint counts, 28 swollen joint counts, the erythrocyte sedimentation rate (ESR), and general health (measured on a visual analog scale \[VAS\] from 0 to 10 cm) are included in the DAS28 score. Scores on the DAS28 range from 0 to 10. A DAS28 score \>5.1 indicates high disease activity, a DAS28 score \<3.2 indicates low disease activity, and a DAS28 score \<2.6 indicates clinical remission.
Baseline and Months 3, 6, 12, 18, 24, 30, 36, 48, and 60
Percentage of Participants in DAS28 Remission
Clinical remission is defined as a DAS28 score of \< 2.6. The Disease Activity Score (DAS28) is a validated index of rheumatoid arthritis disease activity calculated from the 28 tender joint count, 28 swollen joint count, the erythrocyte sedimentation rate (ESR), and the patient's assessment of global disease activity (measured on a visual analog scale \[VAS\] from 0 to 10 cm). Scores on the DAS28 range from 0 to 10; higher scores indicate more disease activity.
Months 3, 6, 12, 18, 24, 30, 36, 48, and 60
Secondary Outcomes (14)
Percentage of Participants With a Significant Therapeutic Response
Baseline and Months 3, 6, 12, 18, 24, 30, 36, 48, and 60
Percentage of Participants With Low, Moderate and High Disease Activity
Baseline and Months 3, 6, 12, 18, 24, 30, 36, 48, and 60
Erythrocyte Sedimentation Rate (ESR) Over Time
Baseline and Months 3, 6, 12, 18, 24, 30, 36, 48, and 60
C-Reactive Protein (CRP) Levels Over Time
Baseline and Months 3, 6, 12, 18, 24, 30, 36, 48, and 60
Tender Joint Count (TJC) Over Time
Baseline and Months 3, 6, 12, 18, 24, 30, 36, 48, and 60
- +9 more secondary outcomes
Study Arms (1)
Rheumatoid arthritis
Participants with rheumatoid arthritis prescribed adalimumab in routine clinical practice were observed from the first dose for up to 5 years.
Eligibility Criteria
General population: patients with rheumatoid arthritis who resided in Germany. German regulations state that all patients are eligible for non-interventional studies; there are no exclusions. Adult patients (≥ 18 years of age) with RA who were preparing to initiate adalimumab therapy according to the product label were eligible for study enrollment. The eligibility criteria below reflect the approved label as stated in the German Summary of Product Characteristics (SPC) for Humira.
You may qualify if:
- Moderate to severe active rheumatoid arthritis in adults with insufficient response to disease-modifying antirheumatic drugs, including methotrexate.
- Moderate to severe active rheumatoid arthritis in adults who have not been treated with methotrexate before.
- In case of incompatibility with methotrexate, adalimumab can be used as monotherapy
You may not qualify if:
- Hypersensitivity against the drug or one of the other ingredients; active tuberculosis or other severe infections (e.g. sepsis and opportunistic infections); moderate to severe cardiac insufficiency
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (370)
Site Reference ID/Investigator# 35034
Aachen, 52062, Germany
Site Reference ID/Investigator# 35033
Aachen, 52064, Germany
Site Reference ID/Investigator# 53919
Achern, 77855, Germany
Site Reference ID/Investigator# 53883
Aichhalden, 78733, Germany
Site Reference ID/Investigator# 35041
Altenburg, 04600, Germany
Site Reference ID/Investigator# 35050
Amberg, 92224, Germany
Site Reference ID/Investigator# 53974
Amberg, 92224, Germany
Site Reference ID/Investigator# 33347
Augsburg, 86150, Germany
Site Reference ID/Investigator# 33356
Bad Abbach, 93077, Germany
Site Reference ID/Investigator# 33359
Bad Abbach, 93077, Germany
Site Reference ID/Investigator# 33362
Bad Aibling, 83043, Germany
Site Reference ID/Investigator# 35084
Bad Aibling, 83043, Germany
Site Reference ID/Investigator# 53968
Bad Aibling, 83043, Germany
Site Reference ID/Investigator# 53966
Bad Bellingen, 79415, Germany
Site Reference ID/Investigator# 35523
Bad Bentheim, D-48455, Germany
Site Reference ID/Investigator# 35571
Bad Bramstedt, 24576, Germany
Site Reference ID/Investigator# 53903
Bad Bramstedt, 24576, Germany
Site Reference ID/Investigator# 53929
Bad Buchau, 88422, Germany
Site Reference ID/Investigator# 33370
Bad Endbach, 35080, Germany
Site Reference ID/Investigator# 33369
Bad Endbach, 63065, Germany
Site Reference ID/Investigator# 33380
Bad Iburg, 49186, Germany
Site Reference ID/Investigator# 33384
Bad Kissingen, 97688, Germany
Site Reference ID/Investigator# 33385
Bad Kreuznach, 55543, Germany
Site Reference ID/Investigator# 33389
Bad Liebenwerda, 04924, Germany
Site Reference ID/Investigator# 53942
Bad Mergentheim, 97980, Germany
Site Reference ID/Investigator# 33394
Bad Münder am Deister, 31848, Germany
Site Reference ID/Investigator# 33398
Bad Nauheim, 61231, Germany
Site Reference ID/Investigator# 33399
Bad Neuenahr, 53474, Germany
Site Reference ID/Investigator# 35576
Bad Neuenahr, 53474, Germany
Site Reference ID/Investigator# 53980
Bad Pyrmont, 31812, Germany
Site Reference ID/Investigator# 33402
Bad Rappenau, 74906, Germany
Site Reference ID/Investigator# 33410
Bad Soden-Salmünster, 63628, Germany
Site Reference ID/Investigator# 33415
Bad Staffelstein, 96231, Germany
Site Reference ID/Investigator# 54804
Bad Tölz, 83646, Germany
Site Reference ID/Investigator# 33423
Baden-Baden, 76530, Germany
Site Reference ID/Investigator# 33427
Bamberg, 96047, Germany
Site Reference ID/Investigator# 33436
Bautzen, 02625, Germany
Site Reference ID/Investigator# 33440
Bayreuth, 95445, Germany
Site Reference ID/Investigator# 53978
Belm, 49191, Germany
Site Reference ID/Investigator# 33449
Bensheim, 64625, Germany
Site Reference ID/Investigator# 33646
Berlin, 10178, Germany
Site Reference ID/Investigator# 53902
Berlin, 10247, Germany
Site Reference ID/Investigator# 33662
Berlin, 10367, Germany
Site Reference ID/Investigator# 33695
Berlin, 10711, Germany
Site Reference ID/Investigator# 34243
Berlin, 10719, Germany
Site Reference ID/Investigator# 33681
Berlin, 10777, Germany
Site Reference ID/Investigator# 35599
Berlin, 12161, Germany
Site Reference ID/Investigator# 53959
Berlin, 12200, Germany
Site Reference ID/Investigator# 33688
Berlin, 12435, Germany
Site Reference ID/Investigator# 34260
Berlin, 12681, Germany
Site Reference ID/Investigator# 33685
Berlin, 13055, Germany
Site Reference ID/Investigator# 53948
Berlin, 13055, Germany
Site Reference ID/Investigator# 53939
Berlin, 13589, Germany
Site Reference ID/Investigator# 53971
Berlin, 13595, Germany
Site Reference ID/Investigator# 53933
Berlin, 14059, Germany
Site Reference ID/Investigator# 53884
Berlin, 14089, Germany
Site Reference ID/Investigator# 33672
Berlin, 14109, Germany
Site Reference ID/Investigator# 35552
Berlin, 14163, Germany
Site Reference ID/Investigator# 35554
Bernau, 16321, Germany
Site Reference ID/Investigator# 53899
Biberach, 88400, Germany
Site Reference ID/Investigator# 34279
Bielefeld, 33611, Germany
Site Reference ID/Investigator# 54810
Bielefeld, 33617, Germany
Site Reference ID/Investigator# 35559
Bietigheim-Bissingen, 74321, Germany
Site Reference ID/Investigator# 35560
Bietigheim-Bissingen, 74321, Germany
Site Reference ID/Investigator# 34283
Blankenburg/Hart, 38889, Germany
Site Reference ID/Investigator# 34286
Blaubeuren Abbey, 89143, Germany
Site Reference ID/Investigator# 34289
Bocholt, 46399, Germany
Site Reference ID/Investigator# 53946
Bocholt, 46399, Germany
Site Reference ID/Investigator# 35567
Bochum, 44789, Germany
Site Reference ID/Investigator# 35642
Bogen, 94327, Germany
Site Reference ID/Investigator# 34300
Bonn, 53111, Germany
Site Reference ID/Investigator# 53969
Bonn, 53129, Germany
Site Reference ID/Investigator# 35647
Bonn, 53175, Germany
Site Reference ID/Investigator# 35648
Bonn, 53175, Germany
Site Reference ID/Investigator# 34294
Bonn, 53177, Germany
Site Reference ID/Investigator# 34305
Braunschweig, 38100, Germany
Site Reference ID/Investigator# 34310
Braunschweig, 38100, Germany
Site Reference ID/Investigator# 35601
Breitenbrunn, 08359, Germany
Site Reference ID/Investigator# 35607
Bremen, 28209, Germany
Site Reference ID/Investigator# 53975
Bremen, 28329, Germany
Site Reference ID/Investigator# 34264
Buch, 13125, Germany
Site Reference ID/Investigator# 53934
Büchen, 21514, Germany
Site Reference ID/Investigator# 34696
Celle, 29221, Germany
Site Reference ID/Investigator# 34700
Chemnitz, 09126, Germany
Site Reference ID/Investigator# 35092
Chemnitz, D-09130, Germany
Site Reference ID/Investigator# 33990
Cologne, 50679, Germany
Site Reference ID/Investigator# 33987
Cologne, 50823, Germany
Site Reference ID/Investigator# 33996
Cologne, 50931, Germany
Site Reference ID/Investigator# 33993
Cologne, 50969, Germany
Site Reference ID/Investigator# 35238
Cologne, 51067, Germany
Site Reference ID/Investigator# 35617
Cottbus, 3048, Germany
Site Reference ID/Investigator# 53987
Cuxhaven, 27474, Germany
Site Reference ID/Investigator# 53889
Cuxhaven, 27476, Germany
Site Reference ID/Investigator# 35622
Darmstadt, 64295, Germany
Site Reference ID/Investigator# 53885
Delmenhorst, 27749, Germany
Site Reference ID/Investigator# 34726
Demmin, 17109, Germany
Site Reference ID/Investigator# 53932
Denkendorf, 73770, Germany
Site Reference ID/Investigator# 35636
Dortmund, 44147, Germany
Site Reference ID/Investigator# 35632
Dortmund, 44263, Germany
Site Reference ID/Investigator# 35171
Dresden, 01097, Germany
Site Reference ID/Investigator# 34762
Dresden, 01109, Germany
Site Reference ID/Investigator# 53958
Dresden, 01159, Germany
Site Reference ID/Investigator# 34749
Dresden, 01277, Germany
Site Reference ID/Investigator# 34763
Dresden, 01307, Germany
Site Reference ID/Investigator# 34776
Duisburg, 47055, Germany
Site Reference ID/Investigator# 53897
Duisburg, 47167, Germany
Site Reference ID/Investigator# 34771
Düsseldorf, 40211, Germany
Site Reference ID/Investigator# 34774
Düsseldorf, 40225, Germany
Site Reference ID/Investigator# 34779
Ebensfeld, 96250, Germany
Site Reference ID/Investigator# 34782
Eberswalde, 16225, Germany
Site Reference ID/Investigator# 54805
Eisenberg, 07607, Germany
Site Reference ID/Investigator# 35180
Elmshorn, 25335, Germany
Site Reference ID/Investigator# 34802
Erftstadt, 50374, Germany
Site Reference ID/Investigator# 34807
Erfurt, 99096, Germany
Site Reference ID/Investigator# 35097
Erfurt, 99096, Germany
Site Reference ID/Investigator# 35189
Erfurt, 99096, Germany
Site Reference ID/Investigator# 54811
Erlangen, 91054, Germany
Site Reference ID/Investigator# 34815
Erlangen, 91056, Germany
Site Reference ID/Investigator# 53925
Essen, 45128, Germany
Site Reference ID/Investigator# 34823
Essen, 45239, Germany
Site Reference ID/Investigator# 35194
Essen, 45326, Germany
Site Reference ID/Investigator# 53931
Essen, 45329, Germany
Site Reference ID/Investigator# 53945
Essen, 45359, Germany
Site Reference ID/Investigator# 34829
Esslingen am Neckar, 73732, Germany
Site Reference ID/Investigator# 35200
Feldafing, 82340, Germany
Site Reference ID/Investigator# 35203
Flensburg, 24937, Germany
Site Reference ID/Investigator# 34831
Forchheim, 91301, Germany
Site Reference ID/Investigator# 34851
Frankfurt, 60590, Germany
Site Reference ID/Investigator# 34838
Frankfurt, 60596, Germany
Site Reference ID/Investigator# 35211
Fraureuth, 08427, Germany
Site Reference ID/Investigator# 35217
Freiberg, 09599, Germany
Site Reference ID/Investigator# 34852
Freiburg im Breisgau, 79098, Germany
Site Reference ID/Investigator# 34855
Freiburg im Breisgau, 79098, Germany
Site Reference ID/Investigator# 53926
Freiburg im Breisgau, 79098, Germany
Site Reference ID/Investigator# 34859
Freiburg im Breisgau, 79106, Germany
Site Reference ID/Investigator# 35099
Freystadt, 92342, Germany
Site Reference ID/Investigator# 53960
Friedberg, 61169, Germany
Site Reference ID/Investigator# 35222
Friedrichroda, 99894, Germany
Site Reference ID/Investigator# 53976
Geesthacht, 21502, Germany
Site Reference ID/Investigator# 53890
Geilenkirchen, 52511, Germany
Site Reference ID/Investigator# 34877
Gelsenkirchen, 45881, Germany
Site Reference ID/Investigator# 53909
Giessen, 35392, Germany
Site Reference ID/Investigator# 53922
Gladbeck, 45964, Germany
Site Reference ID/Investigator# 34894
Goslar, 38642, Germany
Site Reference ID/Investigator# 35231
Göttingen, 37073, Germany
Site Reference ID/Investigator# 65622
Göttingen, 37075, Germany
Site Reference ID/Investigator# 34902
Greifswald, 17491, Germany
Site Reference ID/Investigator# 53957
Groß Reken, 48734, Germany
Site Reference ID/Investigator# 34910
Güstrow, 18273, Germany
Site Reference ID/Investigator# 35501
Hagen, 58089, Germany
Site Reference ID/Investigator# 34924
Halle, 06108, Germany
Site Reference ID/Investigator# 34935
Halle, 06108, Germany
Site Reference ID/Investigator# 34938
Halle, 06108, Germany
Site Reference ID/Investigator# 34920
Halle, 06112, Germany
Site Reference ID/Investigator# 34942
Halle, 06120, Germany
Site Reference ID/Investigator# 33819
Halle, 06128, Germany
Site Reference ID/Investigator# 35442
Hamburg, 20144, Germany
Site Reference ID/Investigator# 53984
Hamburg, 20355, Germany
Site Reference ID/Investigator# 33367
Hamburg, 21031, Germany
Site Reference ID/Investigator# 53900
Hamburg, 21073, Germany
Site Reference ID/Investigator# 34956
Hamburg, 21075, Germany
Site Reference ID/Investigator# 34962
Hamburg, 22081, Germany
Site Reference ID/Investigator# 35450
Hamburg, 22081, Germany
Site Reference ID/Investigator# 35112
Hamburg, 22087, Germany
Site Reference ID/Investigator# 34946
Hamburg, 22089, Germany
Site Reference ID/Investigator# 35001
Hamburg, 22119, Germany
Site Reference ID/Investigator# 34959
Hamburg, 22147, Germany
Site Reference ID/Investigator# 34977
Hamburg, 22147, Germany
Site Reference ID/Investigator# 34965
Hamburg, 22391, Germany
Site Reference ID/Investigator# 54806
Hamburg, 22399, Germany
Site Reference ID/Investigator# 33578
Hamburg, 22529, Germany
Site Reference ID/Investigator# 34967
Hamburg, 22529, Germany
Site Reference ID/Investigator# 34989
Hamburg, 22529, Germany
Site Reference ID/Investigator# 34981
Hamburg, 22609, Germany
Site Reference ID/Investigator# 34984
Hamburg, 22609, Germany
Site Reference ID/Investigator# 34996
Hamburg, 22609, Germany
Site Reference ID/Investigator# 53953
Hamm, 59065, Germany
Site Reference ID/Investigator# 35017
Hanau, 63450, Germany
Site Reference ID/Investigator# 33713
Hanover, 30159, Germany
Site Reference ID/Investigator# 35032
Hanover, 30159, Germany
Site Reference ID/Investigator# 35021
Hanover, 30161, Germany
Site Reference ID/Investigator# 33788
Hanover, 30625, Germany
Site Reference ID/Investigator# 33790
Harrislee, 24955, Germany
Site Reference ID/Investigator# 65629
Haselünne, 49740, Germany
Site Reference ID/Investigator# 33795
Hattingen, 45525, Germany
Site Reference ID/Investigator# 33796
Heidelberg, 69120, Germany
Site Reference ID/Investigator# 33806
Heidelberg, 69121, Germany
Site Reference ID/Investigator# 33811
Heidelberg, D-69115, Germany
Site Reference ID/Investigator# 33816
Heilbad Heiligenstadt, 37308, Germany
Site Reference ID/Investigator# 53911
Herne, 44623, Germany
Site Reference ID/Investigator# 53910
Herne, 44625, Germany
Site Reference ID/Investigator# 65623
Herne, 44652, Germany
Site Reference ID/Investigator# 33823
Herrsching am Ammersee, 82211, Germany
Site Reference ID/Investigator# 33831
Hildesheim, 31124, Germany
Site Reference ID/Investigator# 33836
Hof, 95028, Germany
Site Reference ID/Investigator# 33840
Hofheim, 65719, Germany
Site Reference ID/Investigator# 33843
Hohenfelde, 18209, Germany
Site Reference ID/Investigator# 54807
Homburg, 66424, Germany
Site Reference ID/Investigator# 53985
Illingen, 66557, Germany
Site Reference ID/Investigator# 33933
Ingolstadt, 85049, Germany
Site Reference ID/Investigator# 53938
Jena, 07743, Germany
Site Reference ID/Investigator# 5323
Jena, 07745, Germany
Site Reference ID/Investigator# 33940
Jülich, 52428, Germany
Site Reference ID/Investigator# 33944
Kahla, 07768, Germany
Site Reference ID/Investigator# 35124
Kahla, 07768, Germany
Site Reference ID/Investigator# 33948
Kaiserslautern, 67655, Germany
Site Reference ID/Investigator# 53935
Kaltenkirchen, 24568, Germany
Site Reference ID/Investigator# 33397
Karlsruhe, 76133, Germany
Site Reference ID/Investigator# 33954
Karlsruhe, 76133, Germany
Site Reference ID/Investigator# 35482
Karlstadt am Main, 97753, Germany
Site Reference ID/Investigator# 33962
Kassel, 34131, Germany
Site Reference ID/Investigator# 35239
Kolkwitz, 3099, Germany
Site Reference ID/Investigator# 34000
Königs Wusterhausen, 15711, Germany
Site Reference ID/Investigator# 34006
Kressbronn, 88079, Germany
Site Reference ID/Investigator# 34009
Kronach, 96317, Germany
Site Reference ID/Investigator# 34086
Kyritz, 16866, Germany
Site Reference ID/Investigator# 34003
Lahr, 77933, Germany
Site Reference ID/Investigator# 53937
Leipzig, 04103, Germany
Site Reference ID/Investigator# 65628
Leipzig, 04109, Germany
Site Reference ID/Investigator# 34107
Leipzig, 04207, Germany
Site Reference ID/Investigator# 34098
Leipzig, 04299, Germany
Site Reference ID/Investigator# 34119
Leverkusen, 51373, Germany
Site Reference ID/Investigator# 34121
Lichtenstein, 09350, Germany
Site Reference ID/Investigator# 35252
Lippstadt, 59555, Germany
Site Reference ID/Investigator# 53882
Löhne, 49393, Germany
Site Reference ID/Investigator# 53886
Ludwigsburg, 71638, Germany
Site Reference ID/Investigator# 35257
Ludwigsfelde, 14974, Germany
Site Reference ID/Investigator# 53906
Ludwigslust, 19288, Germany
Site Reference ID/Investigator# 34133
Lübeck, 23552, Germany
Site Reference ID/Investigator# 53943
Lüdenscheid, 58311, Germany
Site Reference ID/Investigator# 33407
Lüneburg, 21335, Germany
Site Reference ID/Investigator# 53888
Lüneburg, 21335, Germany
Site Reference ID/Investigator# 34148
Magdeburg, 39104, Germany
Site Reference ID/Investigator# 53981
Magdeburg, 39110, Germany
Site Reference ID/Investigator# 53913
Magdeburg, 39120, Germany
Site Reference ID/Investigator# 53928
Mainz, 55116, Germany
Site Reference ID/Investigator# 65631
Mainz, 55116, Germany
Site Reference ID/Investigator# 34184
Mannheim, 68165, Germany
Site Reference ID/Investigator# 34194
Marl, 45768, Germany
Site Reference ID/Investigator# 35283
Menz, 39175, Germany
Site Reference ID/Investigator# 53896
Merxheim, 55627, Germany
Site Reference ID/Investigator# 33418
Minden, 32429, Germany
Site Reference ID/Investigator# 34206
Mittelherwigsdorf, 02763, Germany
Site Reference ID/Investigator# 34219
Moenkeberg, 24248, Germany
Site Reference ID/Investigator# 34216
Mönchengladbach, 41061, Germany
Site Reference ID/Investigator# 53915
Mönchengladbach, 41061, Germany
Site Reference ID/Investigator# 34211
Mönchengladbach, 41199, Germany
Site Reference ID/Investigator# 34214
Mönchengladbach, 41199, Germany
Site Reference ID/Investigator# 53904
Munich, 80331, Germany
Site Reference ID/Investigator# 53956
Munich, 80336, Germany
Site Reference ID/Investigator# 34037
Munich, 80639, Germany
Site Reference ID/Investigator# 53962
Munich, 80798, Germany
Site Reference ID/Investigator# 53912
Munich, 81547, Germany
Site Reference ID/Investigator# 35296
Munich, 81667, Germany
Site Reference ID/Investigator# 53924
Munich, 81667, Germany
Site Reference ID/Investigator# 34041
Munich, 81925, Germany
Site Reference ID/Investigator# 34035
Munich, D-81541, Germany
Site Reference ID/Investigator# 34222
Mühlhausen, 99974, Germany
Site Reference ID/Investigator# 34044
Münster, 48143, Germany
Site Reference ID/Investigator# 53970
Münster, 48143, Germany
Site Reference ID/Investigator# 34046
Münster, 48149, Germany
Site Reference ID/Investigator# 34050
Naunhof, 04683, Germany
Site Reference ID/Investigator# 34059
Neubrandenburg, 17033, Germany
Site Reference ID/Investigator# 34062
Neuburg am Inn, 86633, Germany
Site Reference ID/Investigator# 34980
Neunkirchen, 66538, Germany
Site Reference ID/Investigator# 35311
Neuss, 41460, Germany
Site Reference ID/Investigator# 34072
Neustadt, 67434, Germany
Site Reference ID/Investigator# 65630
Neuwied, 56564, Germany
Site Reference ID/Investigator# 82694
Niederbrombach, 55767, Germany
Site Reference ID/Investigator# 34078
Niefern-Öschelbronn, 75223, Germany
Site Reference ID/Investigator# 34081
Nienburg, 31582, Germany
Site Reference ID/Investigator# 34082
Nienburg, 31582, Germany
Site Reference ID/Investigator# 53923
Nuremberg, 90402, Germany
Site Reference ID/Investigator# 34168
Obergünzburg, 87634, Germany
Site Reference ID/Investigator# 34174
Offenburg, 77652, Germany
Site Reference ID/Investigator# 33490
Oldenburg, 26121, Germany
Site Reference ID/Investigator# 53950
Olsberg, 59939, Germany
Site Reference ID/Investigator# 33499
Osnabrück, D-49074, Germany
Site Reference ID/Investigator# 54803
Osnabrück, D-49074, Germany
Site Reference ID/Investigator# 34715
Ostseebad Damp, 24351, Germany
Site Reference ID/Investigator# 35333
Paderborn, 33098, Germany
Site Reference ID/Investigator# 33503
Papenburg, 26871, Germany
Site Reference ID/Investigator# 33506
Parchim, 19370, Germany
Site Reference ID/Investigator# 33509
Parsberg, 92331, Germany
Site Reference ID/Investigator# 35338
Passau, 94032, Germany
Site Reference ID/Investigator# 33511
Petershagen, 32469, Germany
Site Reference ID/Investigator# 33519
Pinneberg, 25421, Germany
Site Reference ID/Investigator# 33520
Pirna, 01796, Germany
Site Reference ID/Investigator# 33521
Planegg, 82152, Germany
Site Reference ID/Investigator# 33526
Plauen, 08523, Germany
Site Reference ID/Investigator# 33468
Potsdam, 14467, Germany
Site Reference ID/Investigator# 33464
Potsdam, 14469, Germany
Site Reference ID/Investigator# 53940
Pulheim, 50259, Germany
Site Reference ID/Investigator# 33482
Radebeul, 01445, Germany
Site Reference ID/Investigator# 53964
Raststatt, 76437, Germany
Site Reference ID/Investigator# 33485
Ratingen, 40882, Germany
Site Reference ID/Investigator# 35134
Ratingen, 40882, Germany
Site Reference ID/Investigator# 54812
Ratingen, 40882, Germany
Site Reference ID/Investigator# 33888
Regensburg, 93049, Germany
Site Reference ID/Investigator# 33891
Regensburg, 93049, Germany
Site Reference ID/Investigator# 33881
Regensburg, 93051, Germany
Site Reference ID/Investigator# 33884
Regensburg, 93051, Germany
Site Reference ID/Investigator# 53930
Regensburg, 93059, Germany
Site Reference ID/Investigator# 53986
Reichenbach, 08468, Germany
Site Reference ID/Investigator# 53920
Remscheid, 42864, Germany
Site Reference ID/Investigator# 33900
Rendsburg, 24768, Germany
Site Reference ID/Investigator# 33903
Reutlingen, 72764, Germany
Site Reference ID/Investigator# 53982
Rheinfelden, 79618, Germany
Site Reference ID/Investigator# 53908
Rickenbach, 79736, Germany
Site Reference ID/Investigator# 33393
Riesa, 01589, Germany
Site Reference ID/Investigator# 33912
Rinteln, 31737, Germany
Site Reference ID/Investigator# 33921
Rostock, 18059, Germany
Site Reference ID/Investigator# 33929
Rothenburg, 02929, Germany
Site Reference ID/Investigator# 34014
Saarbrücken, 66111, Germany
Site Reference ID/Investigator# 34021
Salzwedel, 29410, Germany
Site Reference ID/Investigator# 53916
Schlangenbad, 65388, Germany
Site Reference ID/Investigator# 34030
Schneeberg, 08289, Germany
Site Reference ID/Investigator# 33550
Schwerin, 19053, Germany
Site Reference ID/Investigator# 35374
Schwerin, 19053, Germany
Site Reference ID/Investigator# 33553
Schwerte, 58239, Germany
Site Reference ID/Investigator# 33557
Seesen, 38723, Germany
Site Reference ID/Investigator# 53944
Siegen, 57072, Germany
Site Reference ID/Investigator# 33565
Sinsheim, 74889, Germany
Site Reference ID/Investigator# 53927
Solingen, 42651, Germany
Site Reference ID/Investigator# 33570
Soltau, 29614, Germany
Site Reference ID/Investigator# 33583
Stadtbergen, 86391, Germany
Site Reference ID/Investigator# 33586
Stadthagen, 31655, Germany
Site Reference ID/Investigator# 53936
Steinhagen, 33803, Germany
Site Reference ID/Investigator# 33602
Stuttgart, 70178, Germany
Site Reference ID/Investigator# 33609
Stuttgart, 70199, Germany
Site Reference ID/Investigator# 33596
Stuttgart, 70372, Germany
Site Reference ID/Investigator# 35387
Suhl, 98529, Germany
Site Reference ID/Investigator# 54808
Tarp, 24963, Germany
Site Reference ID/Investigator# 35433
Thum-Jahnsbach, 9419, Germany
Site Reference ID/Investigator# 53951
Tischenreuth, 95643, Germany
Site Reference ID/Investigator# 33623
Torgelow, 17358, Germany
Site Reference ID/Investigator# 33628
Treuenbrietzen, 14929, Germany
Site Reference ID/Investigator# 53907
Tübingen, 72072, Germany
Site Reference ID/Investigator# 53893
Twistringen, 27239, Germany
Site Reference ID/Investigator# 33635
Ueberlingen-Nussdorf, 88662, Germany
Site Reference ID/Investigator# 53898
Uhlstaedt-Kirchhasel, 07407, Germany
Site Reference ID/Investigator# 33722
Ulm, 89073, Germany
Site Reference ID/Investigator# 65626
Ulm, 89073, Germany
Site Reference ID/Investigator# 33732
Verden an der Aller, 27283, Germany
Site Reference ID/Investigator# 53965
Viersen, 41747, Germany
Site Reference ID/Investigator# 33735
Villingen-Schwenningen, 78054, Germany
Site Reference ID/Investigator# 53914
Vogelsang-Gommern, 39245, Germany
Site Reference ID/Investigator# 53952
Vreden, 48691, Germany
Site Reference ID/Investigator# 54809
Waldbronn, 76337, Germany
Site Reference ID/Investigator# 33740
Waltrop, 45731, Germany
Site Reference ID/Investigator# 34250
Wannsee, 14109, Germany
Site Reference ID/Investigator# 33747
Weener, 26826, Germany
Site Reference ID/Investigator# 53891
Weiden I.d. Oberpfalz, 92637, Germany
Site Reference ID/Investigator# 53921
Weißenfels, 06667, Germany
Site Reference ID/Investigator# 33753
Welzow, 03119, Germany
Site Reference ID/Investigator# 35406
Wiesbaden, 65189, Germany
Site Reference ID/Investigator# 53941
Wiesbaden, 65189, Germany
Site Reference ID/Investigator# 33762
Wiesbaden, 65191, Germany
Site Reference ID/Investigator# 33770
Wilhelmshaven, 26382, Germany
Site Reference ID/Investigator# 53954
Winsen, 21423, Germany
Site Reference ID/Investigator# 53977
Winsen, 21423, Germany
Site Reference ID/Investigator# 33778
Wittlich, 54516, Germany
Site Reference ID/Investigator# 33783
Wolfsburg, 38440, Germany
Site Reference ID/Investigator# 53917
Wuppertal, 42103, Germany
Site Reference ID/Investigator# 35418
Wuppertal, 42105, Germany
Site Reference ID/Investigator# 33716
Würzburg, 97070, Germany
Site Reference ID/Investigator# 33862
Zerbst, 39261, Germany
Site Reference ID/Investigator# 33865
Zeven, 27404, Germany
Site Reference ID/Investigator# 33870
Zwickau, 08060, Germany
Site Reference ID/Investigator# 33878
Zwiesel, 94227, Germany
Related Publications (2)
Behrens F, Koehm M, Schwaneck EC, Schmalzing M, Wittig BM, Gnann H, Greger G, Tony HP, Burkhardt H. Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis. Scand J Rheumatol. 2019 Sep;48(5):375-382. doi: 10.1080/03009742.2019.1600717. Epub 2019 Jul 16.
PMID: 31311386DERIVEDScharbatke EC, Behrens F, Schmalzing M, Koehm M, Greger G, Gnann H, Burkhardt H, Tony HP. Association of Improvement in Pain With Therapeutic Response as Determined by Individual Improvement Criteria in Patients With Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2016 Nov;68(11):1607-1615. doi: 10.1002/acr.22884. Epub 2016 Oct 1.
PMID: 26990995DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Global Medical Services
- Organization
- AbbVie (prior sponsor, Abbott)
Study Officials
- STUDY DIRECTOR
Bianca Wittig, MD
AbbVie Deutschland GmbH & Co. KG, Medical Department
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 26, 2010
First Posted
March 2, 2010
Study Start
April 1, 2003
Primary Completion
March 1, 2013
Study Completion
March 1, 2013
Last Updated
May 8, 2014
Results First Posted
April 23, 2014
Record last verified: 2014-04