Discontinuation of Imatinib Mesylate in Patients With Chronic-Phase Chronic Myeloid Leukemia Previously Treated With Interferon-Alpha

NCT01073436 | Terminated DMC

• 2 other identifiers: UMCC 2008.083HUM00021950
• Study Type: observational
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate whether patients with chronic-phase chronic myeloid leukemia (CP-CML) previously treated with interferon-alpha (IFN) and presently on a tyrosine kinase inhibitor (TKI) (imatinib mesylate, dasatinib, or nilotinib) with achievement of a complete cytogenetic and at least a major molecular remission, are able to discontinue therapy and maintain a durable remission. Relapse-free survival (RFS) rate at 1 year after discontinuation of TKI will be the measurement of this objective.

Conditions

Chronic Myeloid Leukemia

Keywords

diagnosis of Ph+) CML in chronic phase.; prior therapy with interferon-alpha for at least 2 years, and achieved at least a partial cytogenetic response; receiving a TKI (imatinib mesylate, dasatinib, nilotinib); WBC ≤ 10 x 109/L.; Platelet count < 450,000 x 109/L.; No blasts or promyelocytes in peripheral blood.; No evidence of disease-related symptoms and extramedullary disease; complete cytogenetic response (CCyR) on a TKI for a minimum of 1 yr; major molecular remission on a TKI for a minimum of 1 yr; 18 years of age or older; ECOG performance status of 0-2 (Appendix 13.1); Informed Consent

Outcome Measures

Primary Outcomes (1)

• Relapse-free survival

  Relapse-free survival (RFS) rate at 1 year after discontinuation of TKI will be the measurement of this objective.

  1 year

Secondary Outcomes (1)

• Reduction of the malignant stem cell population

  1 Year

Study Arms (1)

Discontinuation

Subjects who agree to discontinue their tyrosine kinase inhibitor(TKI)therapy, namely,imatinib mesylate, dasatinib, or nilotinib,and then followed to see if they can maintain a durable remission.

Other: Discontinuation of therapy

Interventions

Discontinuation of therapy OTHER

Patients with chronic-phase chronic myeloid leukemia (CP-CML) previously treated with interferon-alpha (IFN) and presently on a tyrosine kinase inhibitor (TKI) (imatinib mesylate, dasatinib, or nilotinib) with achievement of a complete cytogenetic and at least a major molecular remission.

Discontinuation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Diagnosed with Philadelphia chromosome positive (Ph+) chronic myeloid leukemia in chronic phase.

You may qualify if:

• Patients must have a diagnosis of Philadelphia chromosome positive (Ph+) chronic myeloid leukemia in chronic phase.
• Patients must have received prior therapy with interferon-alpha for their CML, for a period of at least 2 years, and achieved at least a partial cytogenetic response on this therapy, defined as 1% - 34% Ph+ cells in metaphase, present in the bone marrow.
• Patients must be actively receiving treatment for their CML with a TKI (imatinib mesylate, dasatinib, nilotinib). If patients are receiving dasatinib or nilotinib, this can only be for reasons other than imatinib-resistant CML.
• Patients must have an ongoing complete hematologic response (CHR) on a TKI, defined as follows:
• WBC ≤ 10 x 109/L.
• Platelet count \< 450,000 x 109/L.
• No blasts or promyelocytes in peripheral blood.
• No evidence of disease-related symptoms and extramedullary disease, including the liver and spleen.
• Patients must have a complete cytogenetic response (CCyR) on a TKI for a minimum of one year leading up to enrollment. Complete cytogenetic response is defined as 0% Ph+ cells in metaphase, in the bone marrow and/or a negative peripheral blood FISH analysis for the BCR/ABL gene fusion, and an ongoing CCyR must be confirmed by bone marrow aspirate cytogenetics and/or peripheral blood FISH for BCR/ABL within 4 weeks of discontinuing therapy.
• Patients must have at least a major molecular remission on a TKI for a minimum of 1 year, present on 2 consecutive analyses, performed at least 3 months apart, in the 6 to 12 months leading up to enrollment. Major molecular remission is defined as ≥ 3 log reduction from a standard baseline value (equivalent to a BCR-ABL/ABL of ≤ 0.1%) in BCR/ABL transcript by quantitative RT-PCR performed on peripheral blood or bone marrow aspirate. Complete molecular remission is defined as a negative quantitative RT-PCR (QPCR) analysis for BCR/ABL, present on 2 consecutive analyses, performed at least 3 months apart, in the 6 to 12 months leading up to enrollment.
• Patients must be eighteen years of age or older
• Patients must have an ECOG performance status of 0-2 (Appendix 13.1)
• All patients must be informed of the investigational nature of this study and standard alternative therapy. All patients must sign and give written informed consent in accordance with institutional and federal guidelines.

You may not qualify if:

• Patients who have had prior progression of their CML to accelerated phase or blast crisis.
• Patients who have previously undergone hematopoietic stem cell transplantation.
• Patients receiving dasatinib or nilotinib due to a prior history of imatinib-resistant CML.
• Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable.

Sponsors & Collaborators

• University of Michigan Rogel Cancer Center: lead

Study Sites (1)

University of Michigan Cancer Center

Ann Arbor, Michigan, 48109, United States

Location

MeSH Terms

Conditions

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Condition Hierarchy (Ancestors)

Leukemia, Myeloid; Leukemia; Neoplasms by Histologic Type; Neoplasms; Myeloproliferative Disorders; Bone Marrow Diseases; Hematologic Diseases; Hemic and Lymphatic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Dale Bixby, M.D./PhD

  University of Michigan Rogel Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 19, 2010
• First Posted: February 23, 2010
• Study Start: May 1, 2009
• Primary Completion: November 1, 2011
• Study Completion: November 1, 2011
• Last Updated: November 15, 2016

Record last verified: 2016-11

Locations

US (1)