NCT01073332|Completed
The Effects of a Dietary Supplement on Exercise Performance in Healthy Older Adults"
Arginine and Antioxidant Supplement on Performance in Elderly Male Cyclists: A Randomized Controlled Trial
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Arginine and Antioxidant Supplement on Performance in Elderly Male Cyclists: A Randomized Controlled Trial
Sponsor study identifier
interventional
16
1 country
1
Study Start
October 2004
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2005
Actual (reported)Study Completion
February 2005
Actual (reported)Human exercise capacity decreases with aging. One explanation may be that blood vessels stiffen with age and release less of a compound called nitric oxide (NO). This compound normally relaxes blood vessels and increases blood flow to muscles, but damaging compounds called free radicals can interfere with this process. Antioxidants may help prevent free radicals from inactivating nitric oxide. The purpose of this study was to investigate the effects of an antioxidant supplement that supports NO production on exercise performance in elderly male cyclists.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2005
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 2004
Date type not reportedThis date has not been verified as actual or estimated.
February 2005
Actual (reported)February 2005
Actual (reported)February 22, 2010
Actual (reported)February 23, 2010
Actual (reported)Arginine and antioxidant supplements, as compared with placebo will improve exercise performance
3 weeks
Arginine and antioxidant Supplements improve maximal oxygen uptake and anaerobic threshold
3 weeks
The placebo group received a powder with all active ingredients replaced with M-100 maltodextrin.
Dietary Supplement: Niteworks
The proprietary supplement Niteworks® was manufactured by Herbalife International Inc. (Century City, California, USA). Each serving contained 5.2g L-arginine in a proprietary blend with L-citrulline, 500mg ascorbic acid, 400IU vitamin E, 400ug folic acid, 300mg L-taurine, and 10mg alpha lipoic acid in a lemon-flavored powder form. One serving of supplement powder was mixed with 8 oz of water, administered at bedtime based on the rationale that nitric oxide levels are lowest during sleep due to inactivity, lack of food and low blood pressure.
University of California, Los Angeles
Los Angeles, California, 90095, United States
Zhaoping Li, MD, PhD
University of California, Los Angeles
16 participants (actual enrollment reported by the registry).
First Submitted
February 22, 2010
First Posted
February 23, 2010
Study Start
October 2004
Date type not reportedThis date has not been verified as actual or estimated.
The placebo group received a powder with all active ingredients replaced with M-100 maltodextrin.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Primary Completion
February 2005
Actual (reported)Study Completion
February 2005
Actual (reported)Last Updated
May 8, 2015
Record last verified: 2010-02
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Source: ClinicalTrials.gov.
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