Evaluation of Muscle StO2 as a Prognostic Factor After Out of Hospital Cardiac Arrest
1 other identifier
interventional
51
1 country
2
Brief Summary
Out of hospital cardiac arrest is a major health problem. Prognosis is still poor even after return to spontaneous circulation. The pathophysiology of cardiac arrest implies ischemia-reperfusion and sepsis like syndrome. These phenomenons can lead to microvascular dysfunction explaining probably multi-organ failure after cardiac arrest. Few means allow the exploration of microvascular function in human. Muscle StO2 is a technique allowing the assessment of microvascular function non-invasively. The aim of this study is to evaluate muscle StO2 as a prognostic factor after out of hospital cardiac arrest.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Mar 2010
Typical duration for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 22, 2010
CompletedFirst Posted
Study publicly available on registry
February 23, 2010
CompletedStudy Start
First participant enrolled
March 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2013
CompletedMarch 26, 2012
December 1, 2011
3 years
February 22, 2010
March 23, 2012
Conditions
Outcome Measures
Primary Outcomes (1)
Reperfusion slope after vascular occlusion test. This parameter will be compared between survivors and non-survivors
Four measurements : on admission, since the body core temperature reaches 34°, after 24 hours of hypothermia and 48 hours after admission to ICU
Secondary Outcomes (1)
Muscle StO2 during the first 2 days Lactatemia during the first 2 days These parameters will be compared between survivors and non-survivors
Muscle StO2 will be monitored continuously during the first 2 days Lactatemia will be measured every 12 hours until normalization
Interventions
Reperfusion slope after vascular occlusion test
Eligibility Criteria
You may qualify if:
- Out of hospital cardiac arrest
- Patient aged between 18 and 80 years
- Having a Social Security System
You may not qualify if:
- Pregnant women, lack of appropriate consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
CHU de Nice -Hôpital l'Archet
Nice, 06000, France
CHU de Nice Hôpital Saint Roch
Nice, 06000, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jean-Christophe ORBAN, MD
Centre Hospitalier Universitaire de Nice
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Department of Clinical Research and innovation (drc)
Study Record Dates
First Submitted
February 22, 2010
First Posted
February 23, 2010
Study Start
March 1, 2010
Primary Completion
March 1, 2013
Study Completion
March 1, 2013
Last Updated
March 26, 2012
Record last verified: 2011-12