Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure

NCT01065428 | Completed Results DMC

• 1 other identifier: 437129519
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to compare the indices of rapid shallow breathing, neuromechanical efficiency (NME), and neuroventilatory efficiency (NVE) between patients being successfully extubated and those who failed weaning.

Conditions

Respiratory Failure

Keywords

neuromechanical efficiency; neuroventilatory efficiency; weaning; Respiration, Artificial

Outcome Measures

Primary Outcomes (1)

• Neuroventilatory Efficiency (NVE)

  NVE is the ratio of tidal volume and diaphragm electrical activity (Vt/EAdi).It is a value describing how effective a patient's breathing is.

  at 30 minutes of the spontaneous breathing trials (SBT)

Secondary Outcomes (1)

• Neuromechanical Efficiency (NME)

  at 30 minutes of the spontaneous breathing trials (SBT)

Study Arms (2)

Weaning failure

Weaning failure:(1) failed SBT; (2) reintubation and /or resumption of support following successful extubation; or (3) die 48h following extubation.

Weaning successful

Weaning successful:extubation and the absence of ventilatory support 48 h following the extubation

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who required mechanical ventilation for more than 24 h.

You may qualify if:

• We chose a number of eligible patients which were admitted to ICU of the Zhong-Da Hospital and required mechanical ventilation for more than 24 h.

You may not qualify if:

• (1) age \<18 or \>85 years, (2) tracheostomy, (3) treatment abandonment, (4) history of esophageal varices, (5) gastro-esophageal surgery in the previous 12 months or gastro-esophageal bleeding in the previous 30 days, (6) coagulation disorders (INR ratio\>1.5 and APTT\>44 s), (7) history of acute central or peripheral nervous system disorder or severe neuromuscular disease, (8) history of leukemia, severe chronic liver or chronic cardiac disease, (9) solid organ transplantation, (10) malignant tumor

Sponsors & Collaborators

• Southeast University, China: lead
• Unity Health Toronto: collaborator

Study Sites (1)

Nanjing Zhong-Da Hospital

Nanjing, Jiangsu, 21009, China

Location

Related Publications (1)

• Liu L, Liu H, Yang Y, Huang Y, Liu S, Beck J, Slutsky AS, Sinderby C, Qiu H. Neuroventilatory efficiency and extubation readiness in critically ill patients. Crit Care. 2012 Jul 31;16(4):R143. doi: 10.1186/cc11451.

  PMID: 22849707 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Parameters of arterial blood gases, haemodynamic and mechanics of breathing

MeSH Terms

Conditions

Respiratory Insufficiency; Respiratory Aspiration

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Limitations and Caveats

Early termination leading to small numbers of subjects analyzed

Results Point of Contact

• Title: Dr. Haibo Qiu; Dr. Christer Sinderby
• Organization: Department of Critical Care Medicine, Nanjing Zhong-Da Hospital, Southeast University School of Medicine, China

haiboq2000@yahoo.com.cn

008613951965301

Study Officials

• Haibo Qiu, MD, Phd

  Southeast University

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: February 8, 2010
• First Posted: February 9, 2010
• Study Start: December 1, 2008
• Primary Completion: July 1, 2010
• Study Completion: July 1, 2010
• Last Updated: August 31, 2011
• Results First Posted: November 16, 2010

Record last verified: 2011-08

Locations

CN (1)