Intrauterine Human Chorionic Gonadotrophins (hCG) and Endometrial Treg Cells
The Effect of Intrauterine Injection of Human Chorionic Gonadotrophins (hCG) on the Endometrial T-regulatory Cells and the Electronmicroscopic Endometrial Characteristics
1 other identifier
interventional
20
1 country
1
Brief Summary
Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation. It has been demonstrated that regulatory T cells expand during pregnancy. hCG was found to be secreted by the embryo immediately after fertilization and has chemoattractant properties to Treg cells.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Feb 2010
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2010
CompletedFirst Submitted
Initial submission to the registry
February 5, 2010
CompletedFirst Posted
Study publicly available on registry
February 8, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2010
CompletedNovember 5, 2013
December 1, 2010
10 months
February 5, 2010
November 2, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
the presence of Treg cells and pinopodes in the endometrium
4 weeks
Secondary Outcomes (1)
pregnancy rate
4 weeks
Study Arms (1)
intrauterine hCG
EXPERIMENTALintrauterine injection of 100 hCG followed by endometrial biopsy
Interventions
intrauterine injection of 100 IU hCG followed by endometrial biopsy .
Eligibility Criteria
You may qualify if:
- Male factor infertility
- Ovulatory factor infertility
- Unexplained infertility
- Female age less than 39
You may not qualify if:
- Azoospermia
- Tubal factor infertility
- Pelvic endometriosis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Cairo University
Cairo, Egypt
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ragaa Mansour, MD,PhD
The Egyptian IVF-ET Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director, the Egyptian IVF-ET Center
Study Record Dates
First Submitted
February 5, 2010
First Posted
February 8, 2010
Study Start
February 1, 2010
Primary Completion
December 1, 2010
Study Completion
December 1, 2010
Last Updated
November 5, 2013
Record last verified: 2010-12