NCT01054989|CompletedPhase 4DMC
Fat, Inflammation and Insulin Resistance
FIRE
Loading search results
FIRE
Sponsor study identifier
interventional
16
0 countries
N/A
Study Start
March 15, 2009
Actual (reported)Primary Completion
September 15, 2011
Actual (reported)Study Completion
October 15, 2012
Actual (reported)The combination of impaired insulin sensitivity and insulin secretion is thought to be the basis of type 2 diabetes. Increased free fatty acids levels impair insulin action in muscle and liver, but also systemic inflammation processes play a role in the development of insulin resistance. This study compares the effects of fat and inflammation on insulin sensitivity, systemic inflammation, energy metabolism, vascular system and neural function in healthy humans.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 15, 2012
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 15, 2009
Actual (reported)January 22, 2010
Actual (reported)January 25, 2010
Actual (reported)September 15, 2011
Actual (reported)October 15, 2012
Actual (reported)Effect of intervention on whole body insulin sensitivity
6 hours
Effect of intervention on systemic inflammation
1-6 hours
Effect of intervention on cellular immune mechanisms
6 hours
Intravenous application of fat
Oral fat load
Lipopolysaccharide (LPS; US Standard Reference endotoxin)
Fat infusion (Intralipid) over 6 hours Fat orally (Soy bean oil) single dose LPS infusion for 10 minutes Glycerol infusion over 6 hours
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Ziegler D, Strom A, Strassburger K, Nowotny B, Zahiragic L, Nowotny PJ, Carstensen-Kirberg M, Herder C, Szendroedi J, Roden M. Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans. PLoS One. 2015 Apr 20;10(4):e0124242. doi: 10.1371/journal.pone.0124242. eCollection 2015.
Nowotny B, Zahiragic L, Krog D, Nowotny PJ, Herder C, Carstensen M, Yoshimura T, Szendroedi J, Phielix E, Schadewaldt P, Schloot NC, Shulman GI, Roden M. Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans. Diabetes. 2013 Jul;62(7):2240-8. doi: 10.2337/db12-1179. Epub 2013 Mar 1.
Michael Roden, Prof., MD
German Diabetes Center
Bettina Nowotny, MD
German Diabetes Center
16 participants (actual enrollment reported by the registry).
First Submitted
January 22, 2010
First Posted
January 25, 2010
Study Start
March 15, 2009
Actual (reported)Intrevenous glycerol infusion
Contact the study team to confirm eligibility.
Primary Completion
September 15, 2011
Actual (reported)Study Completion
October 15, 2012
Actual (reported)Last Updated
August 20, 2020
Record last verified: 2020-08
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: