Study to Measure the Prevalence of Asynchrony In Mechanically Ventilated Patients

NCT01049958 | Completed

• 1 other identifier: Robinson-2009-01
• Study Type: observational
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine the prevalence of patient-ventilator asynchrony and its determinants. Mechanically ventilated trauma patients often experience asynchrony when their pattern of breathing does not match the triggering of a mechanical ventilator. Asynchrony is thought to be more common in delirious patients, patients with chronic lung disease and those who are heavily sedated. The study will examine the relationship between (1) delirium and sedation and (2) the prevalence of asynchrony in trauma patients.

Conditions

Patient/Ventilator Asynchrony

Keywords

asynchrony; mechanical ventilation; blunt trauma

Outcome Measures

Primary Outcomes (1)

• Proportion of asynchronous breaths

  20 minutes during first 24 hours on ventilation and 20 minutes during weaning phase

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to the Surgical and Neurosurgical Intensive Care Units at University Hospital, Cincinnati, OH, who require mechanical ventilation and are aged 18 years or older.

You may qualify if:

• Trauma or surgical diagnosis
• Patients requiring mechanical ventilation

You may not qualify if:

• Patients with no spontaneous breathing efforts due to injury or chemical paralysis
• Patients with leaks in the patient ventilator system precluding evaluation of waveforms

Sponsors & Collaborators

• University of Cincinnati: lead

Study Sites (1)

University Hospital

Cincinnati, Ohio, 45267, United States

Location

Related Publications (4)

• Thille AW, Rodriguez P, Cabello B, Lellouche F, Brochard L. Patient-ventilator asynchrony during assisted mechanical ventilation. Intensive Care Med. 2006 Oct;32(10):1515-22. doi: 10.1007/s00134-006-0301-8. Epub 2006 Aug 1.

  PMID: 16896854 BACKGROUND

• Fabry B, Guttmann J, Eberhard L, Bauer T, Haberthur C, Wolff G. An analysis of desynchronization between the spontaneously breathing patient and ventilator during inspiratory pressure support. Chest. 1995 May;107(5):1387-94. doi: 10.1378/chest.107.5.1387.

  PMID: 7750336 BACKGROUND

• Nava S, Bruschi C, Fracchia C, Braschi A, Rubini F. Patient-ventilator interaction and inspiratory effort during pressure support ventilation in patients with different pathologies. Eur Respir J. 1997 Jan;10(1):177-83. doi: 10.1183/09031936.97.10010177.

  PMID: 9032512 BACKGROUND

• Robinson BR, Blakeman TC, Toth P, Hanseman DJ, Mueller E, Branson RD. Patient-ventilator asynchrony in a traumatically injured population. Respir Care. 2013 Nov;58(11):1847-55. doi: 10.4187/respcare.02237. Epub 2013 Mar 19.

  PMID: 23513248 DERIVED

MeSH Terms

Conditions

Patient-Ventilator Asynchrony; Wounds, Nonpenetrating

Condition Hierarchy (Ancestors)

Respiratory Insufficiency; Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Wounds and Injuries

Study Officials

• Bryce Robinson, MD

  University of Cincinnati

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 13, 2010
• First Posted: January 15, 2010
• Study Start: July 1, 2009
• Primary Completion: May 1, 2010
• Study Completion: April 1, 2011
• Last Updated: January 15, 2013

Record last verified: 2013-01

Locations

US (1)