Gonadal Steroid Manipulation and Personality Characteristics: Association With Mood Fluctuations and in Vitro Fertilization (IVF) Outcomes

NCT01032421 | Completed

• 1 other identifier: 04-284
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

The current study's primary aim is to investigate the association between neuroendocrine fluctuations and mood disorders by monitoring mood states over distinct hormonal phases during in-vitro-fertilization (IVF) treatment. The secondary goal of this study is to explore psychological profiles and coping mechanisms of women undergoing IVF, and to identify the ones that are associated with successful psychological adaptation to the process and a successful biological outcome.

Conditions

Mood Disorders

Keywords

women admitted to the In Vitro Fertilization unit

Study Arms (1)

GNRH

Observational (IVF is not done as part of the study)

Procedure: IVF procedure

Interventions

IVF procedure PROCEDURE

GNRH

Eligibility Criteria

• Age: Up to 42 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women admitted for their first or second IVF cycle, under the age of 42. Please see the detailed inclusion and exclusion criteria.

You may qualify if:

• Admitted for their first or second IVF cycle;
• Demonstrated sufficient communication skills and level of understanding in the Hebrew language;
• signed an informed consent;
• Were under the age of 42;
• Were not suffering from endometriosis or male factor in patients who underwent testicular sperm extraction (TESE);
• Were not under psychotherapeutic or psychopharmacological treatment. The accepted indications for the IVF included a female factor, male factor or unexplained infertility.

You may not qualify if:

• \. All others.

Sponsors & Collaborators

• Tel-Aviv Sourasky Medical Center: lead

Related Publications (2)

• Zaig I, Azem F, Schreiber S, Amit A, Litvin YG, Bloch M. Psychological response and cortisol reactivity to in vitro fertilization treatment in women with a lifetime anxiety or unipolar mood disorder diagnosis. J Clin Psychiatry. 2013 Apr;74(4):386-92. doi: 10.4088/JCP.12m07805.

  PMID: 23656846 DERIVED

• Bloch M, Azem F, Aharonov I, Ben Avi I, Yagil Y, Schreiber S, Amit A, Weizman A. GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization-embryo transfer cycles. Fertil Steril. 2011 Jan;95(1):307-9. doi: 10.1016/j.fertnstert.2010.07.1073.

  PMID: 20801439 DERIVED

MeSH Terms

Conditions

Mood Disorders

Condition Hierarchy (Ancestors)

Mental Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: November 25, 2009
• First Posted: December 15, 2009
• Study Start: January 1, 2006
• Primary Completion: December 1, 2007
• Study Completion: December 1, 2007
• Last Updated: December 15, 2009

Record last verified: 2009-12