Evaluation of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Oct

NCT01024985 | Unknown

• 1 other identifier: 0190/09
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine the ability of STRATUS OCT and high resolution OCT to detect and to quantify the neural loss in multiple sclerosis and neuromyelitis optica and its subtypes.

Conditions

Multiple Sclerosis; Neuromyelitis Optica

Keywords

optic neuritis; longitudinally extensive transverse myelitis; retinal nerve fiber layer; macular thickness

Study Arms (3)

multiple sclerosis

neuromyelitis optica

controls

Eligibility Criteria

• Age: 15 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

patients of ophthalmology and/or neurology departments of hopital das clinicas of medical school of university of sao paulo

You may qualify if:

• clinical diagnosis of multiple sclerosis or neuromyelitis optica
• age between 15 and 60 years
• BCVA better than 20/400
• no optic neuritis crisis in the last 6 months

You may not qualify if:

• diagnosis of glaucoma, opacities or disc anomalies
• diagnosis of macular disease
• disc swelling at fundoscopy

Sponsors & Collaborators

• University of Sao Paulo: lead

Study Sites (1)

Hospital Das Clinicas Medical School of University of Sao Paulo

São Paulo, São Paulo, 05403-000, Brazil

RECRUITING

Related Publications (2)

• Hokazono K, Raza AS, Oyamada MK, Hood DC, Monteiro ML. Pattern electroretinogram in neuromyelitis optica and multiple sclerosis with or without optic neuritis and its correlation with FD-OCT and perimetry. Doc Ophthalmol. 2013 Dec;127(3):201-15. doi: 10.1007/s10633-013-9401-2. Epub 2013 Jul 30.

  PMID: 23892551 DERIVED

• Monteiro ML, Fernandes DB, Apostolos-Pereira SL, Callegaro D. Quantification of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using Fourier-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Jun 26;53(7):3959-66. doi: 10.1167/iovs.11-9324.

  PMID: 22589446 DERIVED

MeSH Terms

Conditions

Multiple Sclerosis; Neuromyelitis Optica; Optic Neuritis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Myelitis, Transverse; Optic Nerve Diseases; Cranial Nerve Diseases; Eye Diseases

Central Study Contacts

mario luiz r monteiro, phd

CONTACT

55 11 30697871; mlrmonteiro@terra.com.br

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 2, 2009
• First Posted: December 3, 2009
• Study Start: September 1, 2009
• Primary Completion: December 1, 2010
• Study Completion: December 1, 2011
• Last Updated: June 28, 2010

Record last verified: 2010-06

Locations

BR (1)