Effect of Remote Ischemic Preconditioning on Acute Kidney Injury in Patients Undergoing Heart Valve Replacement Surgery With Cardiopulmonary Bypass

NCT01023152 | Completed

• 1 other identifier: 4-2008-0423
• Study Type: interventional
• Target: 74
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to study the effect of remote ischemic preconditioning on acute kidney injury in patients undergoing heart valve replacement surgery with cardiopulmonary bypass.

Conditions

Heart Valve Disease

Study Arms (1)

Automated cuff-inflator

EXPERIMENTAL

Procedure: Automated cuff-inflator

Interventions

Automated cuff-inflator PROCEDURE

RIPC protocol consisted of three 10-min cycles of lower limb ischemia at an inflation pressure of 250 mmHg induced by an automated cuff-inflator placed on the upper leg with an intervening 10 min of reperfusion during which the cuff was deflated.

Automated cuff-inflator

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients undergoing complex valve surgery.

You may not qualify if:

• older than 80 years
• those with left main disease \>50%, or hepatic or pulmonary disease
• active infective endocarditis
• left ventricular ejection fraction \<30%
• myocardial infarction (MI) within 3 weeks
• pre-existing renal dysfunction (serum creatinine (Cr) level \>1.4 mg/dl), and those with peripheral vascular disease affecting the lower limbs.

Sponsors & Collaborators

• Yonsei University: lead

MeSH Terms

Conditions

Heart Valve Diseases

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 1, 2009
• First Posted: December 2, 2009
• Last Updated: December 2, 2009

Record last verified: 2009-12